Comparison of the Incidence of Hypotension in Bolus Versus Continuous Administration of Remimazolam During Anesthesia Induction
Overview
- Phase
- Not Applicable
- Intervention
- Remimazolam bolus
- Conditions
- Hypotension on Induction
- Sponsor
- Kangbuk Samsung Hospital
- Enrollment
- 62
- Primary Endpoint
- Incidence of hypotension
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Remimazolam is a newly introduced intravenous anesthetic, with rapid onset and offset. Although it is known to cause less hemodynamic instability, the incidence hypotension is the one of the most frequent adverse events with its use. For anesthetic induction, remimazolam can be used either as bolus dose or as continuous infusion.
This study is aimed to investigate the incidence of hypotension after anesthetic induction with bolus (0.14-0.33 mg/kg) or continuous (12 mg/kg/hr) remimazolam administration.
Investigators
Eunah Cho, MD
Assistant Professor
Kangbuk Samsung Hospital
Eligibility Criteria
Inclusion Criteria
- •scheduled for elective surgery under general anesthesia
- •adult patient (over 19 years old)
- •American Society of Anesthesiology Physical Status I-III
Exclusion Criteria
- •arrythmia
- •liver dysfunction
- •kidney dysfunction
- •uncontrolled hypertension
- •uncontrolled diabetes mellitus
- •allergic to benzodiazepines
- •heart failure
- •drug intoxication
- •alcohol intoxication
Arms & Interventions
Bolus
Anesthetic induction with bolus remimazolam administration
Intervention: Remimazolam bolus
Continuous
Anesthetic induction with continuous remimazolam administration
Intervention: Remimazolam continuous
Outcomes
Primary Outcomes
Incidence of hypotension
Time Frame: 10 minutes after anesthetic induction
Systolic pressure below 90 mmHg
Secondary Outcomes
- Incidence of bradycardia(10 minutes after anesthetic induction)
- The lowest systolic blood pressure(10 minutes after anesthetic induction)
- Number of participants with vasoactive drug use(10 minutes after anesthetic induction)
- Time to loss of consciousness(10 minutes after anesthetic induction)
- Dosage of remimazolam(10 minutes after anesthetic induction)