Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
Moderate Sedation Combined With Acupuncture Anesthesia in Gastroscopy and Colonoscopy on Screening Research
- Conditions
- Gastrointestinal Endoscopy
- Interventions
- Procedure: eletroacupuncture(transcutaneous electrical acupuncture point stimulation )Drug: placebo needle
- First Posted Date
- 2022-08-03
- Last Posted Date
- 2022-11-04
- Lead Sponsor
- The Affiliated Hospital of Qingdao University
- Target Recruit Count
- 108
- Registration Number
- NCT05485064
- Locations
- 🇨🇳
Jixiangyu, Qingdao, Shandong, China
Remimazolam vs Desflurane for General Anesthesia for Ablation of Arrhythmia
- Conditions
- General AnesthesiaRemimazolamDesfluraneCryoablationArrhythmia
- Interventions
- First Posted Date
- 2022-08-03
- Last Posted Date
- 2023-08-09
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 96
- Registration Number
- NCT05486377
- Locations
- 🇰🇷
Seoul national university Bundang hospital, Seongnam, Province (optional), Korea, Republic of
Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICU
- Conditions
- AnesthesiaLiver FailureMechanical VentilationPharmacokineticsIntensive Care Unit
- Interventions
- First Posted Date
- 2022-07-29
- Last Posted Date
- 2022-07-29
- Target Recruit Count
- 30
- Registration Number
- NCT05480787
- Locations
- 🇨🇳
The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
- Conditions
- Endobronchial MetastasesBronchoesophageal FistulaGeneral Anesthetic Drug Adverse Reaction
- Interventions
- First Posted Date
- 2022-07-21
- Last Posted Date
- 2022-10-26
- Lead Sponsor
- Zhejiang Cancer Hospital
- Target Recruit Count
- 34
- Registration Number
- NCT05468671
- Locations
- 🇨🇳
Zhejiang Cancer Hospital, Hanzhou, China
Median Effective Dose of Remimazolam for Sedation in Elderly Patients
- First Posted Date
- 2022-07-21
- Last Posted Date
- 2023-04-21
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT05468996
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
Effect of Remimazolam on Motor Evoked Potential
- First Posted Date
- 2022-07-12
- Last Posted Date
- 2023-03-15
- Lead Sponsor
- Korea University Guro Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT05453955
- Locations
- 🇰🇷
Seok Kyeong Oh, Seoul, Gangnam-gu, Korea, Republic of
Comparison of Remimazolam and Dexmedetomidine for Intraoperative Sedation
- First Posted Date
- 2022-07-07
- Last Posted Date
- 2022-11-29
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 104
- Registration Number
- NCT05447507
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Jongno-gu, Korea, Republic of
Effect of Remimazolam on Postoperative Nausea and Vomiting
- Conditions
- Postoperative Nausea and Vomiting
- Interventions
- Drug: Control
- First Posted Date
- 2022-06-30
- Last Posted Date
- 2023-07-28
- Lead Sponsor
- Inje University
- Target Recruit Count
- 108
- Registration Number
- NCT05439057
- Locations
- 🇰🇷
Sanggye Paik hospital, Seoul, Korea, Republic of
REmimazolam vs PrOpofol on Intraoperative hypotenSion in Major Noncardiac surgEry
- First Posted Date
- 2022-06-29
- Last Posted Date
- 2025-02-06
- Lead Sponsor
- Nanfang Hospital, Southern Medical University
- Target Recruit Count
- 340
- Registration Number
- NCT05436522
- Locations
- 🇨🇳
Nanfang Hospital, Southern Medical University, Guangzhou, China
Safety and Efficacy Evaluation of Remimazolam for Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy
- Conditions
- Endoscopic Ultrasonography-guided Fine Needle AspirationSedation ComplicationRemimazolam
- Interventions
- First Posted Date
- 2022-06-29
- Last Posted Date
- 2022-06-29
- Target Recruit Count
- 264
- Registration Number
- NCT05437497
- Locations
- 🇨🇳
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
Drug Development Updates
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