Influence of Propofol and Remimazolam on Intraoperative Responses of Motor Evoked Potentials During Spine Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Propofol
- Conditions
- Spine Disease
- Sponsor
- Korea University Guro Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Motor evoked potential (MEP), before cross-over
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This study was planned to investigate the degree of effect of remimazolam on MEP compared to propofol when monitoring the motion-inducing potential (MEP).
Investigators
Seok Kyeong Oh
Assistant Professor
Korea University Guro Hospital
Eligibility Criteria
Inclusion Criteria
- •Aged 20-70
- •Scheduled for elective spine surgery requiring monitoring of evoked potential
- •ASA physical status 1-3
Exclusion Criteria
- •Uncontrolled DM (HbA1c ≥ 9%)
- •Contraindications to the study drug: known allergy or hypersensitivity
- •Use of rate responsive cardiac pacemaker with bioelectrical impedence
- •Diagnosed neuromuscular disorder
- •Pre-existing motor weakness
Arms & Interventions
Propofol-Remimazolam
General anesthesia was induced and maintained with propofol, then switched to remimazolam after 60 minutes from incision.
Intervention: Propofol
Propofol-Remimazolam
General anesthesia was induced and maintained with propofol, then switched to remimazolam after 60 minutes from incision.
Intervention: Remimazolam Besylate
Remimazolam-Propofol
General anesthesia was induced and maintained with remimazolam, then changed to propofol after 60 minutes from incision.
Intervention: Propofol
Remimazolam-Propofol
General anesthesia was induced and maintained with remimazolam, then changed to propofol after 60 minutes from incision.
Intervention: Remimazolam Besylate
Outcomes
Primary Outcomes
Motor evoked potential (MEP), before cross-over
Time Frame: Intraoperative, just after confirmation of neuromuscular recovery, for 30 minutes
Amplitude and latency of MEP before cross-over
MEP, after cross-over
Time Frame: Intraoperative, 30 minutes after alteration of the maintenance drug, for 30 minutes
Amplitude and latency of MEP after cross-over
Secondary Outcomes
- Bispectral index(Intraoperative)
- Heart rate(Intraoperative)
- Blood pressure(Intraoperative)