Comparison of Remimazolam and Propofol Effect on Oxygen Reserve During Endoscopic Retrograde Cholangiopancreatography
Overview
- Phase
- Not Applicable
- Intervention
- Remimazolam besylate
- Conditions
- Hepatobiiliary Diseases Requiring Endoscopic Retrograde Cholangiopancreatography
- Sponsor
- Yonsei University
- Enrollment
- 112
- Locations
- 1
- Primary Endpoint
- Incidence of Oxygen Reserve Index (ORI) drop to 0.00 during sedation
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Propofol is one of the most commonly used sedative in endoscopic procedures, while its potency to induce respiratory depression may threaten patient safety. Remimazolam is known to less likely induce hemodynamic instability when compared to propofol, yet its favorable effects are not clearly evaluated in endoscopic procedures. Hence, this study aimed to compare hemodynamic effects of remimazolam and propofol, by evaluating oxygen reserve index (ORI) in patients scheduled for endoscopic retrograde cholangiopancreatography.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients (age 19\~80 yrs, ASA Class I\~III) who are scheduled for elective endoscopic retrograde cholangiopancreatograph
Exclusion Criteria
- •Pregnancy Allergy to remimazolam or propofol Underlying pulmonary diseases or obstructive sleep apnea Underlying renal (serum Cr \>2mg/dL) or cardiac disease (NYHA class III or IV) Hypotension (SBP \<90mmHg) or hypoxemia (SpO2 \<90%) assessed prior to procedure
Arms & Interventions
Remimazolam
Patient group who receives remimazolam for sedation during endoscopy
Intervention: Remimazolam besylate
Propofol
Patient group who receives propofol for sedation during endoscopy
Intervention: Propofol
Outcomes
Primary Outcomes
Incidence of Oxygen Reserve Index (ORI) drop to 0.00 during sedation
Time Frame: Evaluation begins after sedative administration until the end of endoscopic procedure.
Incidence of Oxygen Reserve Index (ORI) drop to 0.00 will be evaluated after sedative administration, until the end of endoscopic procedure.