Comparison of the effects of remimazolam, propofol, and inhalational agent on postoperative nausea and vomiting: a propensity score matching study.

Suzuki Yuji0 sites4,933 target enrollmentOctober 5, 2021

ConditionsGeneral anesthesia

Overview

Phase: 未知
Intervention: Not specified
Conditions: General anesthesia
Sponsor: Suzuki Yuji
Enrollment: 4933
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

A retrospective, observational, single-center cohort study comparing the occurrence of postoperative nausea and vomiting with remimazolam and propofol anesthesia was conducted. Bias in anesthetic selection was adjusted for using propensity score matching techniques. A total of 1239 subjects were included and 333 pairs were created. Remimazolam anesthesia was associated with a higher incidence of postoperative nausea and vomiting than propofol anesthesia and was robust after propensity score adjustment.

Registry

who.int

Start Date

October 5, 2021

End Date

July 7, 2022

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Suzuki Yuji

Eligibility Criteria

Inclusion Criteria

•All patients who had undergone surgery under general anesthesia at Hamamatsu University Hospital since August 2020\.

Exclusion Criteria

•less than 20 years of age, incorrect enrollment other than general anesthesia, postoperative artificial respiration, cancellation of surgery after induction of anesthesia, lack of consciousness after anesthesia, reoperation within 24 hours after anesthesia, insufficient data due to follow\-up shorter than 24 hours, and maintenance with a combination of propofol and remimazolam.