Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy

Phase 3

Completed

Conditions: Hypotension During Surgery

Interventions: Drug: Remimazolam
Drug: propofol

First Posted Date: 2024-12-03

Last Posted Date: 2024-12-03

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 88

Registration Number: NCT06714669

Locations: 🇨🇳
Sun Yat-san University Cancer Center, Guangzhou, Guangdong, China

The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)

Not Applicable

Recruiting

Conditions: Kidney Failure, Acute
Myopathy; Drugs
Heart Arrhythmia
Succinylcholine Sensitivity
Muscle Relaxation
General Anesthetic Drug Adverse Reaction
Projection

Interventions: Drug: Propofol
Drug: Rocuronium

First Posted Date: 2024-11-27

Last Posted Date: 2024-11-27

Lead Sponsor: 4th Military Clinical Hospital with Polyclinic, Poland

Target Recruit Count: 32

Registration Number: NCT06707532

Locations: 🇵🇱
4th Military Clinical Hospital with Polyclinic, Wrocław, Dolnośląskie, Poland

RCT Comparing Remimazolam With Propofol Under EEG DSA Guidance During Cardiac Electrophysiology Studies and Ablation

Not Applicable

Conditions: Hemodynamic
Remimazolam
Propofol
Cardiac Electrophysiology

Interventions: Drug: Propofol
Drug: Remimazolam
Device: With intubation and controlled ventilation to maintain airway
Device: Maintain spontaneous ventilation without intubation

First Posted Date: 2024-11-22

Last Posted Date: 2024-11-22

Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Target Recruit Count: 200

Registration Number: NCT06700681

Locations: 🇨🇳
Taipei Veterans General Hospital, Taipei, Taiwan

The Effect of Sevoflurane on Airway Hyperreactivity During the Perioperative Period.

Completed

Conditions: RSV Infection in Children Less Than 5 Years of Age
General Anesthesia

Interventions: Drug: Sevoflurane (Volatile Anesthetic)
Drug: propofol

First Posted Date: 2024-11-19

Last Posted Date: 2025-01-22

Lead Sponsor: First Hospital of China Medical University

Target Recruit Count: 97

Registration Number: NCT06694675

Locations: 🇨🇳
First hospital of China Mdical University, Shenyang, Liaoning, China
🇨🇳
First Hospital of China Medical University, Shenyang, Liaoning, China

Clinical Studies of the Efficacy and Safety of Remimazolam for Anesthesia Induction and Maintenance in Elderly Patients

Phase 4

Not yet recruiting

Conditions: Efficacy and Safety

Interventions: Drug: Remimazolam
Drug: Propofol

First Posted Date: 2024-11-15

Last Posted Date: 2024-12-16

Lead Sponsor: Affiliated Hospital of Nantong University

Target Recruit Count: 60

Registration Number: NCT06690424

Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery

Phase 4

Recruiting

Conditions: Postoperative Delirium (POD)

Interventions: Drug: Ciprofol
Drug: Propofol

First Posted Date: 2024-11-05

Last Posted Date: 2025-03-25

Lead Sponsor: Wang Tianlong

Target Recruit Count: 214

Registration Number: NCT06674226

Locations: 🇨🇳
The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
🇨🇳
Tongji Hospital, Wuhan, Hubei, China
🇨🇳
The third Xiangya Hospital of Central South University, Changsha, Hunan, China

and more 4 locations

Comparison of High Flow Vs Standard Nasal Cannula in Children with Burns Under Sedoanalgesia

Not Applicable

Completed

Conditions: Burns

Interventions: Other: Conventional Nasal Cannula
Other: High-flow nasal cannula
Drug: midazolam, ketamine, propofol
Drug: Propofol

First Posted Date: 2024-10-29

Last Posted Date: 2024-11-19

Lead Sponsor: Zeliha Tuncel

Target Recruit Count: 50

Registration Number: NCT06663293

Locations: 🇹🇷
Umraniye Education and Research hospital, Istanbul, Turkey

Sevoflurane and Laryngeal Mask Airway Versus Propofol Infusion and Facemask for EUA in Children

Not Applicable

Completed

Conditions: Anesthesia
Children, Only

Interventions: Drug: Propofol with oxygen via simple mask
Drug: sevoflurane via LMA

First Posted Date: 2024-10-24

Last Posted Date: 2025-05-22

Lead Sponsor: American University of Beirut Medical Center

Target Recruit Count: 60

Registration Number: NCT06656455

Locations: 🇱🇧
American University of Beirut Medical Center, Beirut, Lebanon

Hemodynamic Effects of a High Dose Versus Low Dose Propofol During Induction of Anesthesia.

Not Applicable

Recruiting

Conditions: Hemodynamic Effects of Propofol

Interventions: Drug: Propofol injection

First Posted Date: 2024-10-22

Last Posted Date: 2024-11-26

Lead Sponsor: Ain Shams University

Target Recruit Count: 70

Registration Number: NCT06651749

Locations: 🇪🇬
Ain Shams university, Cairo, Abbaseya, Egypt

Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia

Phase 1

Not yet recruiting

Conditions: Chronic Insomnia
Sleep Deprivation
REM Behavior Disorder
REM Sleep Behavior Disorder
REM Sleep Measurement
Insomnia
Insomnia Related to Specified Disorder
Insomnia Due to Other Mental Disorder
Insomnia Comorbid to Psychiatric Disorder
Insomnia Due to Anxiety and Fear

Interventions: Procedure: PROSOMNIA Sleep Therapy™ (PSTx)
Procedure: Anesthesia-Induced Sleep Therapy
Drug: Diprivan (propofol), Astra-Zeneca
Device: Continuous EEG Monitoring

First Posted Date: 2024-10-16

Last Posted Date: 2024-11-01

Lead Sponsor: Nyree Penn

Target Recruit Count: 100

Registration Number: NCT06644573

Locations: 🇺🇸
PROSOMNIA Sleep Health and Wellness, Aventura, Florida, United States

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