DeepMed Research

Nitrous oxide

Generic Name: Nitrous oxide

Brand Names: Alnox

Drug Type: Small Molecule

Chemical Formula: N_₂O

CAS Number: 10024-97-2

Unique Ingredient Identifier: K50XQU1029

Background: Nitrous oxide, commonly known as "laughing gas", is a chemical compound with the chemical formula N2O. At room temperature, it is a colorless non-flammable gas, with a pleasant, slightly sweet odor and taste. It is used in surgery and dentistry for its anesthetic and analgesic effects. It is known as "laughing gas" due to the euphoric effects of inhaling it, a property that has led to its recreational use as an inhalant drug.

Indication: Not Available

Associated Therapies: Analgesia, General Anesthesia

Clinical Trials

Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery

Phase 1

Completed

Conditions: Anesthesia
Tooth Extraction

Interventions: Drug: Midazolam Hydrochloride
Drug: Fentanyl
Drug: Ketamine
Drug: Propofol injection
Drug: Nitrous oxide

First Posted Date: 2025-03-10

Last Posted Date: 2025-03-10

Lead Sponsor: Albert Einstein College of Medicine

Target Recruit Count: 73

Registration Number: NCT06867068

Locations: 🇺🇸
NYCHHC - Jacobi Medical Center and North Central Bronx Hospital, Bronx, New York, United States

Nitrous Oxide Neuroimaging

Early Phase 1

Recruiting

Conditions: Anesthesia
Pain
Amnesia

Interventions: Drug: Nitrous oxide
Device: Peripheral Nerve Stimulation

First Posted Date: 2024-11-25

Last Posted Date: 2025-02-04

Lead Sponsor: Keith M Vogt

Target Recruit Count: 60

Registration Number: NCT06702631

Locations: 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Nitrous Oxide for Pain Management During In-Office Gynecology Procedures

Early Phase 1

Terminated

Conditions: Nitrous Oxide

Interventions: Drug: IV Sedation
Drug: Nitrous oxide

First Posted Date: 2024-10-28

Last Posted Date: 2024-10-28

Lead Sponsor: University of Arizona

Target Recruit Count: 3

Registration Number: NCT06661005

Locations: 🇺🇸
Banner University Medical Center Phoenix, Phoenix, Arizona, United States

Efficacy of Remifentanil in Preventing Emergence Agitation

Not Applicable

Recruiting

Conditions: Emergence Agitation

Interventions: Drug: Remifentanil
Drug: Fentanyl
Drug: N2O

First Posted Date: 2024-08-06

Last Posted Date: 2024-08-06

Lead Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

Target Recruit Count: 99

Registration Number: NCT06539013

Locations: 🇹🇷
Health Sciences University Gazi Yaşargil Training and Research Hospital, Diyarbakır, Kayapınar, Turkey

Intracervical Balloon Placement With Nitrous Oxide Administration

Phase 3

Recruiting

Conditions: Induced; Birth
Labor Pain

Interventions: Drug: Nitrous oxide
Drug: Oxygen

First Posted Date: 2024-07-12

Last Posted Date: 2024-07-12

Lead Sponsor: Maimonides Medical Center

Target Recruit Count: 162

Registration Number: NCT06498908

Locations: 🇺🇸
Maimonides Medical Center OB/GYN, Brooklyn, New York, United States

Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide

Phase 2

Not yet recruiting

Conditions: Emergency Psychiatric
Suicidal Ideation
Nitrous Oxide

Interventions: Drug: Medical air
Drug: Nitrous oxide

First Posted Date: 2024-05-28

Last Posted Date: 2024-06-07

Lead Sponsor: University Hospital, Tours

Target Recruit Count: 30

Registration Number: NCT06430489

Locations: 🇫🇷
Psychiatric Emergencies, Tours, France

Effect of Nitrous Oxide on Aggression.

Phase 2

Recruiting

Conditions: Intermittent Explosive Disorder

Interventions: Drug: Room Air
Drug: Nitrous oxide

First Posted Date: 2023-11-07

Last Posted Date: 2025-03-27

Lead Sponsor: Ohio State University

Target Recruit Count: 50

Registration Number: NCT06118567

Locations: 🇺🇸
Ohio State University Wexner Medical Center, Columbus, Ohio, United States

Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy

Phase 4

Recruiting

Conditions: Pain Catastrophizing
Procedural Anxiety
Procedural Pain

Interventions: Drug: Nitrous oxide

First Posted Date: 2023-06-08

Last Posted Date: 2024-08-20

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 35

Registration Number: NCT05895383

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Virtual Reality vs Nitrous Oxide in Pediatric Dentistry

Not Applicable

Active, not recruiting

Conditions: Pediatric Dentistry

Interventions: Behavioral: Virtual Reality Headset
Drug: Nitrous Oxide

First Posted Date: 2023-06-06

Last Posted Date: 2025-02-05

Lead Sponsor: Geisinger Clinic

Target Recruit Count: 62

Registration Number: NCT05890898

Locations: 🇺🇸
Geisinger, Danville, Pennsylvania, United States

Virtual Reality Games in Pediatric Surgery

Not Applicable

Recruiting

Conditions: Surgical Procedure, Unspecified
Immersion
Analgesia

Interventions: Other: Virtual reality gaming
Drug: Nitrous oxide

First Posted Date: 2022-08-22

Last Posted Date: 2024-04-11

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 100

Registration Number: NCT05510141

Locations: 🇨🇭
Inselspital Bern, Bern, Switzerland

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