The effect of general anesthesia with desflurane versus propofol on postoperative cognitive dysfunction in the elderly undergoing major urological surgeries: a randomized trial
- Registration Number
- TCTR20210924002
- Lead Sponsor
- Department of Research, Faculty of Medicine Siriraj Hospital Mahidol University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- nknown
- Sex
- Male
- Target Recruitment
- 300
1. Patients with American Society of Anesthesiologists (ASA) physical status 1-3
2. Patients 65 years and older who underwent elective major urological surgery (prostatectomy, cystectomy, nephrectomy, robotic-assisted surgery etc.) and operation time 2-5 hour.
3. Patients who can speak, read and communicate in Thai4. Patient voluntarily participates in the study
1. Patients who participated in other clinical trials in the past 90 days or more 4 times in the past year.
2. A patient who has a history of allergy to anesthetics.
3. A patient who has a condition that affects the mental, such as chronic alcohol consumption. Have a history of chronic opioid use have a psychiatric disorder, depression, or a history of taking psychotropic drugs, etc.
4. The patient has severe visual and hearing impairments, a barrier to communication
5. Patients who refused to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of POCD after general anesthesia with desflurane or propofol at pre-discharge and 3 month after surgery Patient reported outcome using a Montreal Cognitive Assessment Scale (MoCA)
- Secondary Outcome Measures
Name Time Method