IDEAL Care: Identifying Advanced Liver Fibrosis in Primary Care

Not Applicable

• Conditions: iver Fibrosis; Liver Disease; Hepatocellular Carcinoma; Liver Cirrhosis; Liver Elastography; Liver Fibrosis; Cancer - Liver; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Public Health - Health service research; Public Health - Other public health

• Registration Number: ACTRN12623001183673
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-11-16
• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Aged 45 to 75 years on the day prior to the patient’s baseline GP visit or day of GP review of historical FIB-4 is applicable, and one or more of the risk factors below
- Is an active patient at the GP practice
- Have had a minimum of one consultation with a GP during the trial intervention period OR- Patient has FIB-4 calculated (within 3 months of FHT activation) and the result is reviewed by the GP
- Have 1 or more risk factors for chronic liver disease, namely;
---Type 2 diabetes,
--- BMI of 30kg/m2 or terms for ‘obesity’ in addition to a metabolic risk factor (hypertension: BP greater than 130/85 or terms for ‘hypertension’ or active prescription of antihypertensive medication or dyslipidaemia: triglycerides greater than 150mg/dL (greater than 1.70 mmol/L) or HDL-cholesterol less than 40mg/dL (less than 1.0 mmol/L) for men and less than 50 mg/dL (less than 1.3 mmol/L) for women or has pre-diabetes [fasting blood glucose between 6.1-6.9 mmol/l or HbA1c between 6.0-6.4%])
- Elevated liver enzymes in previous 12 months defined as any of these:
---ALT: greater than 30 in men, greater than 19 in women IU/l,
---AST greater than 45 IU/l,

- Chronic viral hepatitis defined as any of these:
---Chronic hepatitis including chronic Hep B or, chronic Hep C (Positive HBsAg, HCV positive Ab)

- Chronic Fatty liver including steatohepatitis and non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD)

- Alcohol abuse and excess alcohol as determined from GP records or AUDIT score:
Equal to 3 for women,
Equal to 4 for men in the past 12 months

Exclusion Criteria

Patients meeting any of the following criteria will be excluded from the trial:
- Existing diagnosis of cirrhosis, hepatocellular carcinoma, hepatic encephalopathy, ascites, or oesophageal varices.
- Pregnancy
- Residential Aged Care Facility (RACF) resident

Study & Design

• Study Type: Interventional
• Study Design: Not specified