Photoacoustic imaging (PAI) of lymphatic vessels in secondary limb lymphedema, a feasibility study
Completed
- Conditions
- ymphedema
- Registration Number
- NL-OMON26096
- Lead Sponsor
- Erasmus University Medical Center Rotterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
•Over 18 years,
•Secondary lymphedema as a result of cancer treatment,
•Secondary lymphedema of one arm or leg,
•Willingness of participation: signed informed consent
Exclusion Criteria
•Presence of an allergic history for iodine,
•Patients where the standard imaging (near-infrared fluorescence imaging) cannot be performed,
•Active infection of the limb,
•Pregnancy (note: most patients will be beyond child bearing age)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main outcome is the possibility of depiction lymphatic vessels and veins in two-dimensional images on locations with lymphatic vessels determined with NIRF-L and locations with dermal backflow and compare PAI and NIRF-L findings.
- Secondary Outcome Measures
Name Time Method Secondary parameters are the depth and diameter of the lymphatic vessels and veins, the possibility of depiction of lymphatic vessels and veins in three-dimensional images and the possibility to detect lymphatic vessels behind dermal backflow patterns.