Multiparametric Imaging for Analysis of MVNT (Multinodular and Vacuolating Neuronal Tumor)

Recruiting

• Conditions: Benign Neuronal Desease

• Registration Number: NCT04103190
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

Differential diagnoses of MVNT include DNT (dysembryoplastic neuroepithelial tumor), low-grade gliomas, cortical dysplasias or even hamartomas.

Detailed Description

Differential diagnoses of MVNT include DNT (dysembryoplastic neuroepithelial tumor), low-grade gliomas, cortical dysplasias or even hamartomas.

However, in order to avoid an invasive surgical procedure to remove the lesion, a certain diagnosis of its benignity is essential. The contribution of advanced techniques in MRI, such as spectroscopy in the characterization of these lesions, has not yet been studied today

Study Timeline

• Study First Submitted: 2019-06-21
• Study First Submitted QC: 2019-09-24
• Study First Posted: 2019-09-25
• Study Start: 2019-12-10
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-10
• Last Update Posted: 2023-07-11
• Primary Completion: 2024-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patient over 18 years old
• Suspicion of MVNT on an MRI: it is considered that it will be necessary at least the 2 major criteria associated with at least 1 minor criterion to enter the definition of suspicion of MVNT:

Major criteria:

• Multinodular aspect in cluster
• High FLAIR hypersignal / T2

Minor criteria:

• Absence of mass effect

• Hyposignal T1

• Center of the lesion in hypsignal FLAIR or T1 hypersignal

  • Affiliate or beneficiary of a Social Security scheme
  • Having received informed information about the study and consenting to participate in the study

Exclusion Criteria

• Patient benefiting from a legal protection measure
• Pregnant or lactating woman
• Contraindication to MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Description of a new radiological entity on Spectroscopy : the MVNT (Multinodular and Vacuolating Neuronal Tumor)	1 day	area under curve of the N-Acetylaspartate Spectroscopie
Description of a new radiological entity on Spectroscopy : : the MVNT (Multinodular and Vacuolating Neuronal Tumor)	1 day	area under curve of choline Spectroscopie

Trial Locations

Locations (7)

Fondation Adolphe de Rothschild; 🇫🇷 Paris, France

Groupe Hospitalier Pellegrin; 🇫🇷 Bordeaux, France

Hôpital Pierre Paul Riquet, CHU Purpan; 🇫🇷 Toulouse, France

CHU Rennes; 🇫🇷 Rennes, France

CHU de Rouen; 🇫🇷 Rouen, France

Hôpital Laennec; 🇫🇷 Saint-Herblain, France

Centre Hospitalier Lyon Sud; 🇫🇷 Pierre Bénite, France