DMS-0901: Multimodal Magnetic Resonance Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas

Dartmouth-Hitchcock Medical Center1 site in 1 country12 target enrollmentApril 2009

ConditionsRecurrent High Grade Gliomas

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Recurrent High Grade Gliomas
Sponsor: Dartmouth-Hitchcock Medical Center
Enrollment: 12
Locations: 1
Primary Endpoint: To prospectively acquire multiparameter MR variables at 1.5T and 3T MRI from treated high grade glioma patients to assign tissue signatures for tumor recurrence and radiation necrosis as established by pathologic examination.
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Brain imaging tests are routinely used to detect the presence of a brain tumor or to evaluate the response to treatment. Sometimes the images obtained are not specific and the only way to establish a diagnosis is by obtaining a tissue sample. The hypotheses of the study is to determine if multimodal MR technique will provide tissue signatures that differentiate between tumor progression and treatment related necrosis in high grade glioma patients.

Registry

clinicaltrials.gov

Start Date

April 2009

End Date

April 2011

Last Updated

12 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Dartmouth-Hitchcock Medical Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Histologically proven high grae glioma with central pathology review at DHMC
•Age 18 equal to or greater than 18 years
•Karnofsky performance greater or equal to 60%
•Patients must have received radiation therapy and chemotherapy but should not have received any anti-angiogenesis therapy.

Exclusion Criteria

•Any patient who requires urgent surgical resection of MRI abnormality would not be eligible
•Pregnant women are not eligible

Outcomes

Primary Outcomes

To prospectively acquire multiparameter MR variables at 1.5T and 3T MRI from treated high grade glioma patients to assign tissue signatures for tumor recurrence and radiation necrosis as established by pathologic examination.

Time Frame: 24 months