MR7T-Healthy-PTX : Brain Exploration in Magnetic Resonance Imaging in Parallel Transmission Mode (pTX) at 7 Tesla
- Conditions
- MRI7 TESLAPTXBRAIN
- Registration Number
- NCT04369755
- Lead Sponsor
- Poitiers University Hospital
- Brief Summary
Magnetic resonance imaging (MRI) is a non-invasive imaging modality used in routine clinical practice for clinical diagnosis by visualizing the anatomical structure and in vivo function of certain organs. The development of ultra-high field MRI systems with 7.0-T or higher, gives access to a new field of exploration of the human body by improving the speed of acquisition but also a better signal-to-noise ratio (SNR) and better resolution. In order to fully exploit the potential of these ultra-high field MRI scanners, various technical issues must be adressed. Indeed, the non-uniformity of the transmission field is one of them leading to non-uniform images with spatially varying contrast. Thus the pTX (parallel transmission) mode using multiple transmission channels allows spatial and temporal control over the RF waves.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Age ≥ 18 years old
- Subject with no MRI contraindications (metallic shine, pacemaker)
- Free subject, without guardianship or curatorship or subordination
- A person affiliated to or beneficiary of a social security scheme.
- Informed and signed consent by the healthy volunteer after clear and fair information about the study
- Subject with a contraindication to MRI (pregnancy, ocular metallic foreign body (accidental or other shrapnel); pacemaker (cardiac stimulator), implantable defibrillator, non MRI 7.0 T compatible neurostimulator, cochlear implants and generally any irremovably implanted electronic medical device; metallic heart valve, vascular clips formerly implanted on cranial aneurysm), metallic prostheses.
- Healthy volunteers suffering from claustrophobia
- Persons not benefiting from a Social Security scheme or not benefiting from it through a third party.
- Persons benefiting from reinforced protection, i.e. minors, pregnant and breastfeeding women, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and finally, patients in emergency situations.
- Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Evaluate the improvement of the Signal to Noise Ratio (SNR) in parallel transmission mode (pTx) versus without pTx at 7.0 T on different cerebral anatomical regions/structures (central gray nuclei, cerebellum, white matter, cortex). 1 year The main evaluation criterion is the value of the signal-to-noise ratio in a global way but also by a unit comparison approach (voxel to voxel).
It will be a question of linking these variations to the flip angles but also to the probable inhomogeneities of the B1+ field.
- Secondary Outcome Measures
Name Time Method Evaluation of the body temperature 1 year Measurement of body temperature in healthy volunteers using a forehead thermometer before and after examination
Evaluation of anxiety before, during and after the MRI 1 year Measurement of the healthy subject's feelings about the exam (anxiety, heat, nausea) using a grid proposed at the end of the exam.
Trial Locations
- Locations (1)
CHU de Poitiers
🇫🇷Poitiers, France
CHU de Poitiers🇫🇷Poitiers, FranceRémy GUILLEVINContact