Pilote Study : Brain Exploration in Magnetic Resonance Imaging in Parallel Transmission Mode (pTX) at 7 Tesla on Healthy Subject at Poitiers University Hospital
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- MRI
- Sponsor
- Poitiers University Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Evaluate the improvement of the Signal to Noise Ratio (SNR) in parallel transmission mode (pTx) versus without pTx at 7.0 T on different cerebral anatomical regions/structures (central gray nuclei, cerebellum, white matter, cortex).
- Last Updated
- 4 years ago
Overview
Brief Summary
Magnetic resonance imaging (MRI) is a non-invasive imaging modality used in routine clinical practice for clinical diagnosis by visualizing the anatomical structure and in vivo function of certain organs. The development of ultra-high field MRI systems with 7.0-T or higher, gives access to a new field of exploration of the human body by improving the speed of acquisition but also a better signal-to-noise ratio (SNR) and better resolution. In order to fully exploit the potential of these ultra-high field MRI scanners, various technical issues must be adressed. Indeed, the non-uniformity of the transmission field is one of them leading to non-uniform images with spatially varying contrast. Thus the pTX (parallel transmission) mode using multiple transmission channels allows spatial and temporal control over the RF waves.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 years old
- •Subject with no MRI contraindications (metallic shine, pacemaker)
- •Free subject, without guardianship or curatorship or subordination
- •A person affiliated to or beneficiary of a social security scheme.
- •Informed and signed consent by the healthy volunteer after clear and fair information about the study
Exclusion Criteria
- •Subject with a contraindication to MRI (pregnancy, ocular metallic foreign body (accidental or other shrapnel); pacemaker (cardiac stimulator), implantable defibrillator, non MRI 7.0 T compatible neurostimulator, cochlear implants and generally any irremovably implanted electronic medical device; metallic heart valve, vascular clips formerly implanted on cranial aneurysm), metallic prostheses.
- •Healthy volunteers suffering from claustrophobia
- •Persons not benefiting from a Social Security scheme or not benefiting from it through a third party.
- •Persons benefiting from reinforced protection, i.e. minors, pregnant and breastfeeding women, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and finally, patients in emergency situations.
- •Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy).
Outcomes
Primary Outcomes
Evaluate the improvement of the Signal to Noise Ratio (SNR) in parallel transmission mode (pTx) versus without pTx at 7.0 T on different cerebral anatomical regions/structures (central gray nuclei, cerebellum, white matter, cortex).
Time Frame: 1 year
The main evaluation criterion is the value of the signal-to-noise ratio in a global way but also by a unit comparison approach (voxel to voxel). It will be a question of linking these variations to the flip angles but also to the probable inhomogeneities of the B1+ field.
Secondary Outcomes
- Evaluation of the body temperature(1 year)
- Evaluation of anxiety before, during and after the MRI(1 year)