Correlation of Automated Pupillometry with Heart Rate Variability for Autonomic Dysfunction Assessment in Craniovertebral Junction and Upper Cervical Spine Pathologies
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 48
- 试验地点
- 1
研究概览
简要总结
This prospective observational study aims to evaluate the relationship between automated pupillometry parameters and heart rate variability (HRV) indices for assessing autonomic dysfunction in patients with craniovertebral junction and upper cervical spine pathologies. Structural abnormalities at the cervicomedullary junction can disrupt autonomic pathways, leading to subclinical dysautonomia and perioperative hemodynamic instability. Heart rate variability is a well-established method for evaluating autonomic function but requires ECG analysis and specialized software. Automated pupillometry is a rapid, non-invasive bedside technique that measures dynamic pupillary responses reflecting autonomic activity. The study will evaluate the correlation between pupillometry-derived parameters and HRV indices to determine whether pupillometry can serve as a reliable bedside screening tool for autonomic dysfunction in this patient population.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 12.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with radiologically confirmed craniovertebral junction (CVJ) or upper cervical spine pathology (e.g., atlantoaxial instability, basilar invagination, Chiari malformation, occipital assimilation, traumatic/degenerative cervical cord compression).
排除标准
- •Ocular pathology affecting pupillary reflex (acute anisocoria, severe cataract, acute glaucoma, recent ocular surgery/trauma) 2) Major cardiac arrhythmias or pacemaker rhythm 3) Chronic systemic illnesses significantly altering autonomic function, including, chronic kidney disease, advanced heart disease/heart failure, diabetes with autonomic neuropathy, severe hypothyroidism, Parkinsonism, known primary dysautonomia 4) Medications strongly altering pupils/autonomics within 24–48h: sympathomimetics/adrenergic agonists or antagonists, Beta-blockers, anticholinergics, opioids/sedatives/benzodiazepines, vasoactive agents, mydriatic/miotic eye drops 5) Raised intracranial pressure, poor neurological status, agitation or inability to cooperate 6) Patients with severe disease who might not tolerate transfer to the testing facility 7) ICU admission/ventilation, sepsis, pregnancy.
研究者
Jerome Kumar R
GB Pant Institute of Postgraduate Medical Education and Research (GIPMER)