Exploring Heart Rate Variability and Pupillometry as Predictors of Sedation Depthin Dexmedetomidine Sedation in Non-Operating Room Anaesthesia (NORA) Settings

This prospective observational study aims to evaluate whether heart rate variability and pupillometry can serve as reliable predictors of sedation depth in adult patients receiving dexmedetomidine sedation in non-operating room anaesthesia (NORA) settings. The study will include patients undergoing procedures such as MRI or minor interventions outside the operating room where dexmedetomidine is used for conscious sedation. Standard sedation scores such as the Richmond Agitation Sedation Scale (RASS) will be used as clinical reference. Physiological parameters including heart rate variability and pupil size will be recorded at predefined time points during sedation. The correlation between these objective parameters and clinical sedation scores will be analyzed to assess their predictive value. The study aims to contribute to safer and more individualized sedation practices in NORA environments.