Supernormal Oxygen Delivery for Patients With Severe Burns

Early Phase 1

• Conditions: Burn Surgery; Dobutamine
• Interventions: Drug: Dobutamine

• Registration Number: NCT05241912
• Lead Sponsor: Guangzhou Red Cross Hospital

Brief Summary

This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the goal-directed fluid therapy group to further evaluate significant differences in rate of complications during burn surgery.

Detailed Description

This is a randomized double-blinded study to investigate the effect of control group and the goal-directed fluid therapy group on complications during surgery of the burn patients. The groups are designated as the control group and the oal-directed fluid therapy group to further evaluate significant differences in complications during the surgery.

Study Timeline

• Status Verified: 2022-01
• Study First Submitted: 2022-02-06
• Study First Submitted QC: 2022-02-06
• Last Update Submitted: 2022-02-06
• Study First Posted: 2022-02-16
• Last Update Posted: 2022-02-16
• Study Start: 2022-02-28
• Primary Completion: 2023-06-01
• Study Completion: 2023-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Severe burn patients

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Exclusion Criteria

• Patients or families refuse to sign consent

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Goal-directed fluid group	Dobutamine	Intervention: administration of dobutamine 0.01 - 0.04 U/min after induction of anesthesia. Intraoperative fluid management: administration of 2-4 ml/kg/hr of crystalloid solution.

Primary Outcome Measures

Name	Time	Method
Complication	One week after operation	perioperative complications

Trial Locations

Locations (1)

Guangzhou Red cross hospital; 🇨🇳 Guangzhou, Guangdong, China