Supernormal Oxygen Delivery May Not be a Valid Goal for Patients With Proximal Femur Fracture. An Observational Pilot Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Oxgen delivery index
研究概览
简要总结
This is an observational pilot study of supernormal oxygen delivery goal for patients with proximal femoral fracture.
详细描述
Augmentation of oxygen delivery using fluids with or without inotropes has been shown to improve surgical outcome in high-risk patients. Patients with proximal femoral fracture are considered high risk. However, most of this cohort elderly patients have poor cardiovascular condition and may not achieve the oxygen delivery goal. We will perform an observational pilot study whether the supernormal oxygen delivery is a valid hemodynamic goal for patients with proximal femoral fracture.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged over 70 yr
- •Weight over 35 kg
- •Underwent proximal femur fracture (PFF) surgery under peripheral nerve block and laryngeal mask airway anesthesia.
排除标准
- •Patients who could be harmed due to the treatment (ongoing myocardial infarction, chronic dialysis)
- •Monoamine oxidase inhibitor use within the last 14 days
- •Pathological fractures and conditions
- •Inability to give informed consent(as judged by a research team member)
- •Anticipated difficulties obtaining data during the first postoperative year (as judged by a research team member)
结局指标
主要结局
Oxgen delivery index
时间窗: At the end of 4 hour goal-directed therapy
To attain a improved oxygen delivery index at the end of 4 hour goal-directed therapy
次要结局
- Hear rate augmentation(Day 1)
- Hemodynamic response(Day 1)
- fluid volume administrated(intraoperatively)
- Length of hospital stay(Day 30)
- Postoperative morbidity(day 5)
研究者
Xiangcai Ruan
Vice-Chair
Guangzhou First People's Hospital