Impact of Acute Stress and Its Habituation on Brain Energy Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Stress induced changes in glucose metabolism
研究概览
简要总结
Background: Stress plays an essential role in the pathophysiology of mental disorders. However, individual differences in the vulnerability to acute and repeated stress are not well understood.
Aim: This work aims to investigate individual differences in glucose metabolism and directional connectivity regulating the neuronal stress response.
Design: 68 healthy volunteers will undergo two simultaneous PET/MRI measurements one week apart. Participants will complete the Montreal Imaging Stress Test during each measurement and in-between. Effects of stress on cognitive performance will be assessed using the n-back working memory task. Individual cortisol levels will be acquired to identify stress (non)responders as well as (non)habituators.
Implications: This work will characterize differences between stress responders vs. non-responders and stress habituators vs. non-habituators in terms of energy metabolism and network connectivity. This individual difference in the stress response may represent an important cornerstone for future evaluation of patients with mental disorders.
详细描述
Methodological details: Each participant will undergo two PET/MRI scans. Imaging will include functional PET and as well as structural and functional MRI. Stress-specific glucose metabolism will be quantified with the radioligand [18F]FDG. Functional connectivity will be combined with glucose metabolism to assess directional connectivity. Based on previous literature, changes are expected to occur in the anterior cingulate cortex.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-40 years
- •right-handedness
- •willingness and competence to sign the informed consent form
排除标准
- •History of or current physical, neurological or psychiatric disorder
- •History of or current substance abuse or medication, including antipsychotic, antidepressant and antianxiety agents
- •Pregnancy of current breast-feeding
- •Contraindications for MRI-scanning (e.g., metal implants, steel grafts, etc.), including dental implants causing signal artifacts
- •For subjects participating in earlier studies using ionizing radiation, the total radiation exposure of 30 mSv over the last 10 years must not be exceeded, as specified in the Austrian legislation on radiation protection Accordingly, body weight > 105 kg is an exclusion criterion.
- •Failure to comply with the study protocol or to follow the instructions of the investigating team.
结局指标
主要结局
Stress induced changes in glucose metabolism
时间窗: 1 week
Glucose metabolism will be quantified from \[18F\]FDG PET imaging.
次要结局
- Stress induced changes in directional connectivity(1 week)
- Stress induced changes in cognitive performance(1 week)
研究者
Rupert Lanzenberger
Prof. PD MD, Head Neuroimaging Labs
Medical University of Vienna