Behavioural and neuroimaging effects of stress, habits and attachment in obsessive-compulsive disorder (SHA-OCD)

Zon MW0 个研究点目标入组 46 人开始时间: 2019年2月21日最近更新: 2023年4月10日

适应症

试验速览

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32094333/ (added 27/03/2023)

•1. Diagnosis of OCD with obsessions and compulsions assessed with the MINI Neuropsychiatric Interview (MINI)
•2. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 12
•3. 18-65 years of age
•4. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
•1. 18-65 years of age
•2. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

•1. Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI
•2. Major head trauma or neurological disease, current or in history
•3. MRI contraindications such as metal implants, claustrophobia, left-handedness, pregnancy
•4. Self-reported inability or unease to cease smoking for 3 hours prior to testing
•5. Endocrinological disorders or regular use of corticosteroids
•6. Current treatment with antipsychotic medication
•7. Use of other psychotropic medication (apart from SSRI's or tricyclic antidepressant), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
•8. Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
•1. Current or past psychiatric diagnosis as assessed with the MINI
•2. Major head trauma or neurological disease, current or in history
•3. MRI contraindications such as metal implants, claustrophobia, pregnancy
•4. Self-reported inability or unease to cease smoking for 24 hours prior to testing
•5. Endocrinological disorders or regular use of corticosteroids
•6. Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
•7. Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).

发起方

Zon MW