Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
- Conditions
- Acute Myocardial Infarction
- Interventions
- Combination Product: PlaceboCombination Product: Selatogrel
- Registration Number
- NCT04957719
- Lead Sponsor
- Idorsia Pharmaceuticals Ltd.
- Brief Summary
This study will randomize patients recently discharged from the hospital with a confirmed diagnosis of type 1 acute myocardial infarction (Thygesen et al. 2018) and having additional cardiovascular risk factors.
- Detailed Description
The purpose of this study is to assess the clinical efficacy of selatogrel when self-administered upon occurrence of symptoms suggestive of an acute myocardial infarction (AMI) in participants at risk of having a recurrent AMI.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 14000
-
Confirmed diagnosis of symptomatic type 1 acute myocardial infarction (AMI) ST-Elevation Myocardial Infarction (STEMI) or Non-ST-Elevation Myocardial Infarction (NSTEMI), no longer than 4 weeks prior to randomization.
-
Diagnosis of multivessel coronary artery disease defined as ≥ 50% stenosis on 2 or more coronary artery territories, including the left main artery, during a prior cardiac catheterization or cardiac catheterization during the qualifying AMI event and presence of at least 1 of the following risk factors:
- Second prior AMI,
- Diabetes mellitus defined by ongoing glucose lowering treatment,
- Chronic kidney disease defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m2 and either known history of chronic kidney disease or a biomarker of chronic kidney damage,
- Peripheral artery disease at any time prior to randomization,
- Absence of, or unsuccessful coronary revascularization of the qualifying AMI.
-
Successful self-administered placebo according to the autoinjector instruction for use training during screening.
Main
-
Increased risk of serious bleeding including any of the following:
- History of intracranial bleed at any time.
- Known uncorrected intracranial vascular abnormality.
- Gastrointestinal bleed requiring hospitalization or transfusion within 1 year prior to screening.
- Already on oral triple antithrombotic therapy (i.e., Dual antiplatelet therapy and oral anticoagulant).
- Known liver impairment significantly affecting the hepatic function.
- Current dialysis.
- Ischemic stroke or transient ischemic attack within 3 months of screening.
-
Chronic anemia with hemoglobin < 10 g/dL.
-
Chronic thrombocytopenia with platelet count < 100,000/mm3.
-
Known hypersensitivity to selatogrel, any of its excipients, or drugs of the P2Y12 class.
-
Previous exposure to an investigational drug within 3 months prior to randomization.
-
Participation in another clinical trial with an investigational product or device within 3 months prior to randomization.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Study treatment administration may occur at any time between the randomization visit and the final study visit when the participant experiences symptoms suggestive of an acute myocardial infarction. Study treatment administration triggers protocol pre-defined assessments or visits. Selatogrel Selatogrel Study treatment administration may occur at any time between the randomization visit and the final study visit when the participant experiences symptoms suggestive of an acute myocardial infarction. Study treatment administration triggers protocol pre-defined assessments or visits.
- Primary Outcome Measures
Name Time Method Clinical status as assessed by a 6-point ordinal scale Total duration: up to 7 days The clinical status will be assessed using a 6-point ordinal scale after any study treatment self-administration. Only the worst clinical outcome will be retained as the primary efficacy outcome. The 6 mutually exclusive outcomes ranked from worst to best are:
1. Death (all causes), within 7 days after study treatment administration.
2. Acute myocardial infarction with compromised electro-hemodynamics, within 2 days after study treatment administration.
3. ST-Elevation Myocardial Infarction (STEMI), within 2 days after study treatment administration.
4. High-risk Non-ST-Elevation Myocardial Infarction (NSTEMI), within 2 days after study treatment administration.
5. NSTEMI with peak cardiac troponin greater than 10 times upper limit of normal, within 2 days after study drug administration.
6. None of the aboveOccurrence of Type 3 or 5 treatment-emergent bleeding events according to the Bleeding Academic Research Consortium (BARC) definition Total duration: up to 2 days The number of:
* Type 3 treatment-emergent bleeding events and
* Type 5 treatment-emergent bleeding events
will be assessed according to the Bleeding Academic Research Consortium (BARC) definition (Mehran et al. 2011), within 2 days after study treatment administration.
The Bleeding Academic Research Consortium (BARC) definitions are:
* Type 3, bleeding is divided into 3 categories, a through c, and includes clinical, laboratory, and/or imaging evidence of bleeding with specific healthcare provider responses.
* Type 5, bleeding is fatal.
- Secondary Outcome Measures
Name Time Method Occurrence of death, non-fatal acute myocardial infarction, hospitalization or unplanned emergency department visit for heart failure (Composite endpoint) Total duration: up to 30 days Occurrence death, non-fatal acute myocardial infarction, hospitalization or unplanned emergency department visit for heart failure within 30 days after any self-administration.
Trial Locations
- Locations (444)
University Hospital Leuven (UZ Leuven)
🇧🇪Leuven, Belgium
AZ Delta Campus Rumbeke
🇧🇪Roeselare, Belgium
Lianyungang First People's Hospital
🇨🇳Lianyungang, China
Liaocheng people's Hospital
🇨🇳Liaocheng, China
The North Estonia Medical Centre
🇪🇪Tallinn, Estonia
Heart Clinic, Tartu University Hospital
🇪🇪Tartu, Estonia
Jorvi Hospital, Helsinki University Hospital
🇫🇮Espoo, Finland
Bnai Zion Medical Center, Cardiology
🇮🇱Haifa, Israel
Edith Wolfson Medical Center
🇮🇱H̱olon, Israel
Boca Clinical Trials México, SC (Puebla)
🇲🇽Puebla, Mexico
SMIQ / Boca Clinical Trials México
🇲🇽Queretaro, Mexico
Klinicko bolnicki centar, Bežanijska kosa
🇷🇸Belgrade, Serbia
Kliničko Bolnički Centar Bežanijska Kosa
🇷🇸Belgrade, Serbia
Klinički centar Kragujevac
🇷🇸Kragujevac, Serbia
Opšta bolnica Leskovac
🇷🇸Leskovac, Serbia
Klinički Centar Niš
🇷🇸Niš, Serbia
Premedix Clinic
🇸🇰Bratislava, Slovakia
University Hospital Bratislava
🇸🇰Bratislava, Slovakia
Cardiocentre CINRE
🇸🇰Bratislava, Slovakia
Konstantopouleio - Patision General Hospital of Nea Ionia
🇬🇷Nea Ionia, Greece
University Hospital of Heraklion
🇬🇷Heraklion, Greece
Thriasio General Hospital
🇬🇷Magoula, Greece
Sismanoglio Hospital of GNA "Sismanoglio - Amalia Fleming
🇬🇷Marousi, Greece
University Hospital of Patras
🇬🇷Patras, Greece
Aristotle University of Thessaloniki (AUTH) - University General Hospital of Thessaloniki (AHEPA)
🇬🇷Thessaloníki, Greece
San Donato Hospital, U.O.C. Cardiology
🇮🇹Arezzo, Italy
Ospedale Maggiore Bologna - Dept. Cardiology
🇮🇹Bologna, Italy
AORN "Sant'Anna e San Sebastiano"
🇮🇹Caserta, Italy
Azienda Ospedaliero-Universitaria Policlinico ""G. Rodolico - San Marco
🇮🇹Catania, Italy
Clin Hosp Ctr Zemun - Cardiology Dept
🇷🇸Belgrade, Serbia
Department of Cardiology, Clinical Hospital Center Zemun
🇷🇸Belgrade, Serbia
Viborg Hospital
🇩🇰Viborg, Denmark
UMHATEM N I Pirogov EAD
🇧🇬Sofia, Bulgaria
The Third Hospital of Shijiazhuang
🇨🇳Shijiazhuang, China
Fakultní nemocnice Plzen
🇨🇿Pilsen, Czechia
Kardiologie Praha s.r.o.
🇨🇿Prague 10, Czechia
General Faculty Hospital
🇨🇿Prague 2, Czechia
Hospital Center Departmental Vendée
🇫🇷La Roche-sur-Yon, France
CH Chartres
🇫🇷Le Coudray, France
CHU Timone 2
🇫🇷Marseille, France
Hôpital Arnaud de Villeneuve
🇫🇷Montpellier, France
Clinique du Millénaire
🇫🇷Montpellier, France
Univ Hosp de Nimes Carémeau
🇫🇷Nîmes, France
University Hospitals Pitié Salpêtrière
🇫🇷Paris, France
Klinikum Klagenfurt am Woerthersse
🇦🇹Klagenfurt, Austria
Bichat-Claude Bernard Hospital
🇫🇷Paris, France
Universitätsklinikum St. Pölten
🇦🇹Sankt Pölten, Austria
Nouvel Hopital Civil
🇫🇷Strasbourg, France
Klinik Ottakring
🇦🇹Vienna, Austria
MyMichigan Medical Center - Midland
🇺🇸Midland, Michigan, United States
Hosp Rangueil - Cardiology A Dept
🇫🇷Toulouse, France
Karl Landsteiner Institut für Kardiovaskuläre und Intensivmedizinische Forschung
🇦🇹Vienna, Austria
Ippokrateio (Hyppokration) General Hospital of Athens
🇬🇷Athens, Greece
Advanced Heart Care, LLC
🇺🇸Bridgewater, New Jersey, United States
Amarillo Heart Clinical Research Institute Inc.
🇺🇸Amarillo, Texas, United States
PharmaTex Research
🇺🇸Amarillo, Texas, United States
OLV Aalst
🇧🇪Aalst, Belgium
University General Hospital "Attikon"
🇬🇷Athens, Greece
MHAT South-West Hospital, Cardiology Department
🇧🇬Sandanski, Bulgaria
Colorado Heart and Vascular PC
🇺🇸Golden, Colorado, United States
UVA University Hospital
🇺🇸Charlottesville, Virginia, United States
Tasmanian Health at Royal Hobart Hospital
🇦🇺Hobart, Australia
Wollongong Hospital - Illawarra Shoalhaven Local Health District
🇦🇺Wollongong, Australia
Northeast Arkansas Charitable Foundation, Inc.- NEA Baptist Clinic
🇺🇸Jonesboro, Arkansas, United States
South Denver Cardiology Associates, PC
🇺🇸Littleton, Colorado, United States
Inova Heart & Vascular Institute
🇺🇸Falls Church, Virginia, United States
LKH Universitätsklinikum Graz
🇦🇹Graz, Austria
John Muir Health
🇺🇸Concord, California, United States
Virginia Heart
🇺🇸Falls Church, Virginia, United States
Hospital Oost-Limburg (ZOL)
🇧🇪Genk, Belgium
Long Beach VA Healthcare System
🇺🇸Long Beach, California, United States
San Francisco VA Health Care System"
🇺🇸San Francisco, California, United States
SHATC Sveti Georgi
🇧🇬Pernik, Bulgaria
Advanced Cardiovascular, LLC
🇺🇸Alexander City, Alabama, United States
Birmingham VA Health Care System
🇺🇸Birmingham, Alabama, United States
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Cardiovascular Associates of the Southeast
🇺🇸Birmingham, Alabama, United States
Grandview Medical Center and Affinity Cardiovascular Specialists, LCC
🇺🇸Birmingham, Alabama, United States
Heart Center Research, LLC
🇺🇸Huntsville, Alabama, United States
Dignity Health Mercy Gilbert Medical Center
🇺🇸Gilbert, Arizona, United States
Mayo Clinic Arizona
🇺🇸Phoenix, Arizona, United States
University of Arizona - Sarver Heart Center
🇺🇸Tucson, Arizona, United States
Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center
🇺🇸Torrance, California, United States
Interventional Cardiology Medical Group
🇺🇸West Hills, California, United States
AZ Sint-Lucas
🇧🇪Gent, Belgium
Christiana Care Health Services, Inc.
🇺🇸Newark, Delaware, United States
MedStar Washington Hospital Center
🇺🇸Washington, District of Columbia, United States
Bay Area Cardiology Associates, P.A.
🇺🇸Brandon, Florida, United States
Clearwater Cardiovascular Consultants
🇺🇸Safety Harbor, Florida, United States
Pioneer Clinical Studies (PCS)
🇺🇸Coral Gables, Florida, United States
University of Florida Health Science Center at Jacksonville
🇺🇸Jacksonville, Florida, United States
Baptist Health Research Institute
🇺🇸Jacksonville, Florida, United States
Baptist Health Care, Inc. d/b/a Baptist Hospital Cardiology
🇺🇸Pensacola, Florida, United States
Ascension Sacred Heart
🇺🇸Pensacola, Florida, United States
Atlanta VA Medical Center
🇺🇸Decatur, Georgia, United States
Endeavor Health
🇺🇸Glenview, Illinois, United States
OSF HealthCare Cardiovascular Institute
🇺🇸Peoria, Illinois, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
Indiana University Health Ball Memorial Hospital
🇺🇸Muncie, Indiana, United States
Reid Physician Associates
🇺🇸Richmond, Indiana, United States
St. Elizabeth Healthcare
🇺🇸Edgewood, Kentucky, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
Grace Research, LLC
🇺🇸Bossier City, Louisiana, United States
Northern Light Eastern Maine Medical Center
🇺🇸Bangor, Maine, United States
Sinai Hospital Baltimore, LifeBridge Health
🇺🇸Baltimore, Maryland, United States
Adventist Healthcare White Oak Medical Center
🇺🇸Silver Spring, Maryland, United States
Regions Hospital
🇺🇸Saint Paul, Minnesota, United States
Cardiology Associates Research
🇺🇸Tupelo, Mississippi, United States
University of Missouri Healthcare
🇺🇸Columbia, Missouri, United States
North Kansas City Hospital
🇺🇸North Kansas City, Missouri, United States
Saint Michael's Medical Center
🇺🇸Newark, New Jersey, United States
Rutgers New Jersey Medical School
🇺🇸Newark, New Jersey, United States
AtlantiCare Regional Medical Center
🇺🇸Pomona, New Jersey, United States
St. Joseph's Hospital Cardiology
🇺🇸Liverpool, New York, United States
VA NY Harbor Healthcare System
🇺🇸New York, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Moses H. Cone Memorial Hospital Operation Corporation d/b/a Cone Health
🇺🇸Greensboro, North Carolina, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Wellspan Chambersburg Hospital
🇺🇸Chambersburg, Pennsylvania, United States
Penn State Health Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Penn State Health Medical Group - Berks Cardiology
🇺🇸Wyomissing, Pennsylvania, United States
Prisma Health - Upstate
🇺🇸Greenville, South Carolina, United States
Upstate Cardiology
🇺🇸Greenville, South Carolina, United States
Monument Health Clinical Research, Monument Health Rapid City Hospital Inc.
🇺🇸Rapid City, South Dakota, United States
CHI Institute for Research and Innovation
🇺🇸Chattanooga, Tennessee, United States
Baptist Clinical Research Institute
🇺🇸Memphis, Tennessee, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Covenant Medical Group d/b/a Parkway Cardiology Associates
🇺🇸Oak Ridge, Tennessee, United States
Cardiovascular Research of Knoxville
🇺🇸Powell, Tennessee, United States
Bon Secours St. Mary's Hospital of Richmond, LLC
🇺🇸Richmond, Virginia, United States
Aurora St. Luke's Medical Center
🇺🇸Milwaukee, Wisconsin, United States
The Prince Charles Hospital
🇦🇺Chermside, Australia
Concord Repatriation General Hospital (CRGH) (Concord Hospital)
🇦🇺Concord, Australia
Hospital de Amor Barretos - Fundação PIO XII
🇧🇷Barretos, Brazil
Santa Casa de Misericordia de Belo Horizonte
🇧🇷Belo Horizonte, Brazil
CARDRESEARCH - Cardiologia Assistencial e de Pesquisa
🇧🇷Belo Horizonte, Brazil
Sociedade Hospitalar Angelina Caron
🇧🇷Campina Grande do Sul, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas
🇧🇷Campinas, Brazil
Ebserh Hospital Universitário Maria Aparecida Pedrossian da Univ.Federal de Mato Grosso-HUMAP-UFMS
🇧🇷Campo Grande, Brazil
Galileo Medical Research LTDA
🇧🇷Juiz de Fora, Brazil
Hospital Santa Izabel - Santa Casa de Misericórdia da Bahia
🇧🇷Salvador, Brazil
Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
🇧🇷São Paulo, Brazil
Mbal Puls
🇧🇬Blagoevgrad, Bulgaria
UMHAT Deva Maria
🇧🇬Burgas, Bulgaria
MHAT Ivan Skenderov EOOD
🇧🇬Gotse Delchev, Bulgaria
Medical Centre Avitzena
🇧🇬Kardzhali, Bulgaria
MHAT Cardiolife OOD
🇧🇬Lovech, Bulgaria
University of Calgary Foothills Medical Centre
🇨🇦Calgary, Alberta, Canada
Royal Alexandra Hospital
🇨🇦Edmonton, Alberta, Canada
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
Grey Nuns Community Hospital
🇨🇦Edmonton, Alberta, Canada
Queen Elizabeth II Health Sciences Centre
🇨🇦Halifax, Nova Scotia, Canada
Wiliam Osler Health System
🇨🇦Brampton, Ontario, Canada
Cambridge Cardiac Care Center
🇨🇦Cambridge, Ontario, Canada
York PCI Group, Inc.
🇨🇦Newmarket, Ontario, Canada
Kawartha Cardiology Clinical Trials
🇨🇦Peterborough, Ontario, Canada
St. Michael's Hospital
🇨🇦Toronto, Ontario, Canada
Clinique de Cardiologie de Lévis
🇨🇦Lévis, Quebec, Canada
Montreal Heart Institute
🇨🇦Montréal, Quebec, Canada
CHUM - Centre hospitalier de l'Universite de Montreal"
🇨🇦Montréal, Quebec, Canada
Hôpital du Sacré-Coeur de Montréal
🇨🇦Montréal, Canada
Centre Intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
🇨🇦Trois-Rivières, Quebec, Canada
University of Ottawa Heart Institute
🇨🇦Ottawa, Canada
Diex Research, Inc.
🇨🇦Trois-Rivieres, Canada
Cec-Suecia
🇨🇱Santiago, Chile
Pontificia Universidad Catolica de Chile
🇨🇱Santiago, Chile
Clinica Ensenada
🇨🇱Santiago, Chile
Hospital San Jose de Victoria
🇨🇱Victoria, Chile
Beijing Anzhen Hospital, Capital Medical University
🇨🇳Beijing, China
Beijing Luhe Hospital, Capital Medical University
🇨🇳Beijing, China
Beijing Pinggu Hospital
🇨🇳Beijing, China
The First Bethune Hospital of Jilin University
🇨🇳Changchun, China
The Second Hospital of Jilin University
🇨🇳Changchun, China
Xiangya Hospital Central South University
🇨🇳Changsha, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, China
The Third Xiangya Hospital of Central South University
🇨🇳Changsha, China
West China Hospital of Sichuan University
🇨🇳Chengdu, China
The Second Hospital of Dalian Medical University
🇨🇳Dalian, China
Daqing Oilfield General hospital
🇨🇳Daqing, China
Beijing Hospital
🇨🇳Dongcheng, China
Fujian Provincial Hospital
🇨🇳Fuzhou, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, China
The First Affiliated Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Sir Run Run Shaw Hospital (SRRSH), affiliated with the Zhejiang University School of Medicine
🇨🇳Hangzhou, China
The First Affiliated Hospital of USTC(Anhui Provincial Hospital)
🇨🇳Hefei, China
Shandong University Qilu Hospital
🇨🇳Jinan, China
The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)
🇨🇳Jinan, China
The Second Hospital of Shandong University
🇨🇳Jinan, China
Jining No.1 People's Hospital
🇨🇳Jining, China
Linyi People's Hospital
🇨🇳Linyi, China
Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital
🇨🇳Nanchong, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, China
Nanjing Jiangning Hospital
🇨🇳Nanjing, China
Nanyang Central Hospital
🇨🇳Nanyang, China
Nanyang Second People's Hospital
🇨🇳Nanyang, China
Qingdao Municipal Hospital
🇨🇳Qingdao, China
Shanghai Ninth People's hospital, Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, China
Shanghai Chest Hospital ,Shanghai Jiao Tong University School of Medicine
🇨🇳Shanghai, China
Shanghai General Hospital
🇨🇳Shanghai, China
Renji Hospital, Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, China
The People's Hospital of Liaoning Province
🇨🇳Shenyang, China
The Second Hospital of Hebei Medical University
🇨🇳Shijiazhuang, China
Shanxi Cardiovascular Hospital
🇨🇳Taiyuan, China
Tangshan Central Hospital
🇨🇳Tangshan, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
Tianjin Chest Hospital
🇨🇳Tianjin, China
Teda International Cardiovascular Hospital
🇨🇳Tianjin, China
The Central Hospital of Wuhan
🇨🇳Wuhan, China
Wuhan Asia Heart Hospital
🇨🇳Wuhan, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, China
The First Affiliated Hospital of Xi'an Jiaotong University
🇨🇳Xi'an, China
Northern Jiangsu People's Hospital
🇨🇳YangZhou, China
Yiyang Central Hospital
🇨🇳Yiyang, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, China
Zibo Central Hospital
🇨🇳Zibo, China
Cardiomet Cequin S.A.S
🇨🇴Armenia, Colombia
Administradora Country S.A.S. - Clinica del Country
🇨🇴Bogota, Colombia
Hospital Universitario San Ignacio
🇨🇴Bogotá, Colombia
Fundación Cardioinfantil - Instituto de Cardiología
🇨🇴Bogotá, Colombia
Fundación Valle del Lili
🇨🇴Cali, Colombia
IPS Centro Médico Julián Coronel S.A.S
🇨🇴Cali, Colombia
Clinica Imbanaco S.A.S
🇨🇴Cali, Colombia
Fundación cardiovascular de Colombia
🇨🇴Floridablanca, Colombia
Hospital Alma Mater de Antioquia
🇨🇴Medellin, Colombia
Rodrigo Botero SAS
🇨🇴Medellin, Colombia
Clinica Cardio VID
🇨🇴Medellín, Colombia
University Hospital Brno
🇨🇿Brno, Czechia
ICRC St. Anne University Hospital
🇨🇿Brno, Czechia
University hospital Hradec Králové
🇨🇿Hradec Kralove, Czechia
Regional Hospital Jihlava
🇨🇿Jihlava, Czechia
Regional Hospital Liberec
🇨🇿Liberec, Czechia
Nemocnice Pardubickeho kraje, a.s. - Pardubicka nemocnice
🇨🇿Pardubice, Czechia
Institutu Klinicke a Experimentalni Mediciny (IKEM) (Institute for Clinical and Experimental Medicine)
🇨🇿Prague 4, Czechia
Univ. Hospital Vinohrady
🇨🇿Prague, Czechia
Kardiologie Vinohrady s.r.o.
🇨🇿Praha 1 - Nové Mesto, Czechia
Všeobecná fakultní nemocnice
🇨🇿Praha, Czechia
Olomuc Cardiology
🇨🇿Prostějov, Czechia
University Hospital Ústí nad Labem
🇨🇿Ústí Nad Labem, Czechia
Regional Hospital Ceské Budejovice
🇨🇿České Budějovice, Czechia
Aalborg University Hospital Cardiology
🇩🇰Aalborg, Denmark
Aarhus University Hospital
🇩🇰Aarhus, Denmark
Esbjerg Hospital
🇩🇰Esbjerg, Denmark
Rigshospitalet
🇩🇰Hellerup, Denmark
Goedstrup Region Hospital
🇩🇰Herning, Denmark
Herning Hospital
🇩🇰Herning, Denmark
Odense Universitetshospital
🇩🇰Odense, Denmark
Zealand University Hospital
🇩🇰Roskilde, Denmark
Svendborg Hospital
🇩🇰Svendborg, Denmark
Heart and Lung Center, Helsinki University Hospital
🇫🇮Helsinki, Finland
North Karelian Central Hospital
🇫🇮Joensuu, Finland
StudyCor
🇫🇮Jyväskylä, Finland
Kokkola Central Hospital
🇫🇮Kokkola, Finland
Kuopio University Hospital
🇫🇮Kuopio, Finland
Oulu University Hospital
🇫🇮Oulu, Finland
Seinäjoki Central Hospital
🇫🇮Seinäjoki, Finland
TAYS Tutkimusvastaanotto / TAYS Research Center
🇫🇮Tampere, Finland
Heart Center, Turku University Hospital
🇫🇮Turku, Finland
Hopital Cardiologique CHU Bordeaux
🇫🇷Pessac, Gironde, France
CHRU Brest - Cavale Blanche
🇫🇷Brest, France
CHU Caen · Unité Cardiologie et Pathologie Vasculaire
🇫🇷Caen, France
CHRU Nancy
🇫🇷Vandœuvre-lès-Nancy, France
Aleksandere Aladashvili Clinic
🇬🇪Tbilisi, Georgia
Acad. G. Chapidze Emergency Cardiology Center
🇬🇪Tbilisi, Georgia
Bokhua Memorial CardioVascular Center
🇬🇪Tbilisi, Georgia
Tbilisi Heart and Vascular Clinic Ltd.
🇬🇪Tbilisi, Georgia
TIM Hospital
🇬🇪Tbilisi, Georgia
LTD "Tbilisi Heart Center"
🇬🇪Tbilisi, Georgia
Universitätsklinikum Freiburg; Universitäts-Herzzentrum Freiburg-Bad Krozingen
🇩🇪Bad Krozingen, Germany
Herz- und Diabeteszentrum NRW
🇩🇪Bad Oeynhausen, Germany
MedicTRials STUG - Praxis Dr. Toursarkissian
🇩🇪Berlin, Germany
Vivantes Netzwerk für Gesundheit GmbH
🇩🇪Berlin, Germany
Vivantes Klinikum Spandau
🇩🇪Berlin, Germany
St. Johannes Hospital Dortmund
🇩🇪Dortmund, Germany
Herzzentrum Dresden GmbH; Universitätsklinik an der Technischen Universität Dresden
🇩🇪Dresden, Germany
Universitätsklinikum Hamburg Eppendorf
🇩🇪Hamburg, Germany
SRH Klinikum Karlsbad-Langensteinbach GmbH
🇩🇪Karlsbad, Germany
Krankenhaus der Augustinerinnen Köln gGmbH
🇩🇪Köln, Germany
Universitätsklinikum Köln
🇩🇪Köln, Germany
Herzzentrum Leipzig GmbH
🇩🇪Leipzig, Germany
Gesellschaft für Klinische Forschung mbH Ludwigshafen
🇩🇪Ludwigshafen, Germany
Uniklinikum Magdeburg A. ö. R.
🇩🇪Magdeburg, Germany
Universitätsmedizin Mannheim
🇩🇪Mannheim, Germany
München Klinik Neuperlach
🇩🇪München, Germany
Studienzentrum Innere Med. II Kardiologie, Universitätsklinikum Regensburg
🇩🇪Regensburg, Germany
Robert-Bosch Krankenhaus Stuttgart
🇩🇪Stuttgart, Germany
Krankenhaus der Barmherzigen Brüder
🇩🇪Trier, Germany
Universitätsklinikum Tübingen, Medizinische Klinik Innere Medizin III Kardiologie und Angiologie
🇩🇪Tübingen, Germany
Siteworks GmbH Prüfzentrum Völklingen
🇩🇪Völklingen, Germany
Helios Universitätsklinikum Wuppertal
🇩🇪Wuppertal, Germany
University General Hospital of Alexandroupolis
🇬🇷Alexandroupolis, Greece
General Hospital of Thessaloniki G.Papanikolaou
🇬🇷Thessaloníki, Greece
Asklepeion General Hospital, Voula
🇬🇷Voula, Greece
Állami Szívkorhaz
🇭🇺Balatonfüred, Hungary
Betegápoló Irgalmasrend Budai Irgalmasrendi Kórház, Kardiológia
🇭🇺Budapest, Hungary
Gottsegen György Országos Kardiovaszkuláris Intézet
🇭🇺Budapest, Hungary
Budapesti Bajcsy-Zsilinszky Hospital
🇭🇺Budapest, Hungary
Semmelweis Egyetem Városmajori Szív- és Érgyógyászati Klinika Kardiológia
🇭🇺Budapest, Hungary
Magyar Honvédség Egészségügyi Központ
🇭🇺Budapest, Hungary
Uzsoki Utcai Kórház
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Központ Kardiológiai és Szívsebészeti Klinika
🇭🇺Debrecen, Hungary
Bács-Kiskun Megyei Kórház a Szegedi Tudományegyetem Általános Orvostudományi Kar Oktató Kórháza
🇭🇺Kecskemét, Hungary
SzSzBV Egyetemi Oktatókórház, Nyíregyházi Jósa András Tagkórház, Kardiológia
🇭🇺Nyíregyháza, Hungary
Szegedi Tudományegyetem ÁOK Szent-Györgyi Albert Klinikai Központ II.sz. Belgyógyászati Klinika és Kardiológiai Központ
🇭🇺Szeged, Hungary
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház-Rendelőintézet
🇭🇺Szolnok, Hungary
Léda-Platán Magánklinika
🇭🇺Zalaegerszeg, Hungary
Soroka University Medical Center
🇮🇱Beer-Sheva, Israel
Hillel Yaffee Medical Center, Cardiology Department
🇮🇱Hadera, Israel
Rambam Health Care Campus
🇮🇱Haifa, Israel
Shaare Zedek Medical Center, Cardiology Department
🇮🇱Jerusalem, Israel
Hadassah Hospital on Mount Scopus
🇮🇱Jerusalem, Israel
Meir Medical Center
🇮🇱Kfar Sava, Israel
Galilee Medical Center
🇮🇱Nahariya, Israel
Rabin Medical Center
🇮🇱Petah tikva, Israel
Kaplan Medical Center, Intensive Cardiac Care Unit
🇮🇱Rehovot, Israel
Tel-Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Leviev Heart Center, Sheba Medical Center
🇮🇱Tel Hashomer, Israel
Ziv Medical Center
🇮🇱Zefat, Israel
Shamir Medical Center (Assaf Harofeh)
🇮🇱Zerifin, Israel
Azienda Ospedaliero-Universitaria Policlinico "G. Rodolico - San Marco"
🇮🇹Catania, Italy
AOU Mater Domini
🇮🇹Catanzaro, Italy
University Hospital of Ferrara, Cardiology Unit
🇮🇹Cona, Italy
"SOD Cardiologia Interventistica Strutturale, AOU Careggi
🇮🇹Firenze, Italy
A.O.U. Policlinico Gaetano Martino
🇮🇹Messina, Italy
University of Naples "Federico II"
🇮🇹Napoli, Italy
AOU San Luigi Gonzaga Hospital
🇮🇹Orbassano, Italy
Azienda Ospedaliera di Perugia
🇮🇹Perugia, Italy
A.O.U.Città della Salute e della Scienza di Torino
🇮🇹Torino, Italy
Cardiology Department - Santa Chiara Hospital
🇮🇹Trento, Italy
Infermi Hospital in Rivoli (Turin)
🇮🇹Turin, Italy
Hospital of Lithuanian University of Health Sciences Kauno Klinikos
🇱🇹Kaunas, Lithuania
Klaipeda Seamen's Hospital
🇱🇹Klaipeda, Lithuania
Republican Panevezys Hospital
🇱🇹Panevezys, Lithuania
Vilnius University Hospital Santaros Klinikos
🇱🇹Vilnius, Lithuania
Hospital Cardiológica Aguascalientes
🇲🇽Aguascalientes, Mexico
Boca Clinical Trials México, SC (CDMX)
🇲🇽Ciudad de Mexico, Mexico
Centro para el desarrollo de la medicina y de asistencia médica especializada S.C.
🇲🇽Culiacán, Mexico
Instituto Nacional de Cardiología "Ignacio Chávez"
🇲🇽Mexico City, Mexico
Fundación de Atención e Investigación Médica Lindavista S.C
🇲🇽Mexico City, Mexico
Centro de Atención e Investigación Cardiovascular del Potosí, S.C.
🇲🇽San Luis Potosí, Mexico
Centro Potosino de Investigación Médica S.C.
🇲🇽San Luis Potosí, Mexico
Jeroen Bosch Ziekenhuis
🇳🇱's-Hertogenbosch, Netherlands
Noordwest Ziekenhuisgroep
🇳🇱Alkmaar, Netherlands
Meander Medisch Centrum
🇳🇱Amersfoort, Netherlands
Onze Lieve Vrouwe Gasthuis, locatie Oost
🇳🇱Amsterdam, Netherlands
Amsterdam UMC
🇳🇱Amsterdam, Netherlands
Gelre Ziekenhuis Apeldoorn
🇳🇱Apeldoorn, Netherlands
Deventer Ziekenhuis
🇳🇱Deventer, Netherlands
Albert Schweitzer Ziekenhuis
🇳🇱Dordrecht, Netherlands
Gelderse Vallei Ziekenhuis
🇳🇱Ede, Netherlands
Catharina Hospital
🇳🇱Eindhoven, Netherlands
UMC Groningen
🇳🇱Groningen, Netherlands
Zuyderland Medical Center
🇳🇱Heerlen, Netherlands
Vasculair Onderzoek Centrum Hoorn
🇳🇱Hoorn, Netherlands
Medisch Centrum Leeuwarden
🇳🇱Leeuwarden, Netherlands
Radboud UMC
🇳🇱Nijmegen, Netherlands
Canisius-Wilhelmina Ziekenhuis
🇳🇱Nijmegen, Netherlands
Bravis Ziekenhuis
🇳🇱Roosendaal, Netherlands
Ziekenhuis Rivierenland
🇳🇱Tiel, Netherlands
Elisabeth-TweeSteden Ziekenhuis
🇳🇱Tilburg, Netherlands
Diakonessenhuis Utrecht
🇳🇱Utrecht, Netherlands
Máxima Medisch Centrum
🇳🇱Veldhoven, Netherlands
Waikato Hospital
🇳🇿Hamilton, New Zealand
Taranaki Base Hospital
🇳🇿New Plymouth, New Zealand
Akershus University Hospital
🇳🇴Lørenskog, Norway
Diakonhjemmet Hospital
🇳🇴Oslo, Norway
Oslo University Hospital Rikshospitalet
🇳🇴Oslo, Norway
Oslo University Hospital, Ullevål hospital
🇳🇴Oslo, Norway
Sykehuset Østfold Kalnes (Trust)
🇳🇴Sarpsborg, Norway
Vestfold Hospital
🇳🇴Tønsberg, Norway
Invasive Cardiology Department, University Teaching Hospital in Białystok
🇵🇱Białystok, Poland
Specjalistyczna Praktyka Lekarska Paweł Grzelakowski Centrum Kardiologii Paewł Grzelakowski
🇵🇱Bydgoszcz, Poland
Uniwersyteckie Centrum Kliniczne
🇵🇱Gdansk, Poland
Górnośląskie Centrum Medyczne w Katowicach, III Oddział Kardiologii
🇵🇱Katowice, Poland
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kardiologii oraz Interwencji Sercowo-Naczyniowych
🇵🇱Kraków, Poland
Miedziowe Centrum Zdrowia Regionalny, Ośrodek Kardiologiczny, Pracownia Angiografii i Hemodynamiki
🇵🇱Lublin, Poland
Wojewodzki Szpital Specj im.W Bieganskiego
🇵🇱Lódz, Poland
Wojewódzki Szpital Specjalistyczny w Olsztynie, Oddział Kardiologii
🇵🇱Olsztyn, Poland
INKARD Sp. Z O.O. Sp. JAWNA
🇵🇱Poznan, Poland
Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu
🇵🇱Poznań, Poland
Oddzial Kardiologii i intensywnej Terapii Kardiologicznej
🇵🇱Toruń, Poland
Pracownia Kardiologii Inwazyjnej I Katedry i Kliniki Kardiologii Uniwersyteckiego Centrum Klinicznego Warszawskiego Uniwersytetu Medycznego
🇵🇱Warsaw, Poland
Narodowy Instytut Kardiologii
🇵🇱Warsaw, Poland
The Provincial Specialist Hospital in Wloclawek
🇵🇱Wloclawek, Poland
T.Marciniak Hosp
🇵🇱Wroclaw, Poland
Uniwersytecki Szpital Kliniczny we Wroclawiu
🇵🇱Wrocław, Poland
SCCS Zabrze I i II Oddział Kardiologii i Angiologii
🇵🇱Zabrze, Poland
Nzoz Salusmed Jan Zbigniew Peruga Pphu Salus Poradnia Kardiologiczna
🇵🇱Łódź, Poland
Unidade Local de Saúde de Almada-Seixal, E.P.E.
🇵🇹Almada, Portugal
Unidade Local de Saúde da Região de Aveiro, E.P.E.
🇵🇹Aveiro, Portugal
Unidade Local de Saude de Coimbra EPE
🇵🇹Coimbra, Portugal
Unidade Local de Saúde da Região de Leiria, E.P.E.
🇵🇹Leiria, Portugal
Unidade Local de Saúde de Santa Maria, E.P.E.
🇵🇹Lisboa, Portugal
Spitalul Judetean de Urgenta ""Dr. Constantin Opris" Baia Mare
🇷🇴Baia Mare, Romania
Spitalul Judetean de Urgenta "Dr. Constantin Opris" Baia Mare
🇷🇴Baia Mare, Romania
County Clinical Emergency Hospital Brasov
🇷🇴Braşov, Romania
Spitalul Clinic de Urgenta Bucuresti
🇷🇴Bucharest, Romania
Institutul Inimii de Urgență pentru Boli Cardiovasculare "Niculae Stăncioiu"
🇷🇴Cluj-Napoca, Romania
Spitalul Clinic Judetean de Urgenta Cluj Napoca
🇷🇴Cluj-Napoca, Romania
Spitalul Judetean de Urgenta Satu Mare
🇷🇴Satu Mare, Romania
County Clinical Emergency Hospital Targu Mures
🇷🇴Targu Mures, Romania
Institute of Cardiovascular Diseases Timisoara
🇷🇴Timişoara, Romania
Kliničko bolnički centar "Zvezdara"
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia (Department for Cardiovascular Disease Cardiology Clinic)
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia (Diagnostic and Catheterization Lab)
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia (Emergency Cardiology Services)
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
University Hospital Centre Dr Dragiša Mišovic - Dedinje
🇷🇸Belgrade, Serbia
Dedinje Cardiovascular Institute
🇷🇸Belgrade, Serbia
Institute of Cardiovascular Diseases, Vojvodina
🇷🇸Sremska Kamenica, Serbia
Opšta bolnica Užice
🇷🇸Užice, Serbia
Zdravstveni Centar Zajecar
🇷🇸Zaječar, Serbia
Central Slovak Institute of Cardiovascular Diseases
🇸🇰Banska Bystrica, Slovakia
Východoslovenský ústav srdcových a cievnych chorôb
🇸🇰Košice, Slovakia
Kardiocentrum Nitra
🇸🇰Nitra, Slovakia
Hospital Universitari Germans Trias i Pujol
🇪🇸Badalona, Spain
Hospital de La Santa Creu I Sant Pau
🇪🇸Barcelona, Spain
Hospital Clinic. Barcelona
🇪🇸Barcelona, Spain
Hospital Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Spain
Hospital Universitari de Bellvitge
🇪🇸L'Hospitalet De Llobregat, Spain
Hospital Universitario de la Princesa
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario Virgen de la Victoria
🇪🇸Málaga, Spain
Hospital Clinico Universitario de Santiago
🇪🇸Santiago De Compostela, Spain
Hospital Clinico Valencia
🇪🇸Valencia, Spain
Hospital Alvaro Cunqueiro, Cardiovascular Unit
🇪🇸Vigo, Spain
Universitätsspital Basel; Universitäres Herzzentrum
🇨🇭Basel, Switzerland
Inselspital, Universitäatspital Bern, Universitäatklinik für Kardiologie
🇨🇭Bern, Switzerland
Istituto Cardiocentro Ticino
🇨🇭Lugano, Switzerland
HOCH Health Ostschweiz, Kantonsspital St. Gallen
🇨🇭Saint Gallen, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung City, Taiwan
Chang Gung Medical Foundation-Kaohsiung
🇨🇳Kaohsiung, Taiwan
Mackay Memorial Hospital Tamsui
🇨🇳New Taipei City, Taiwan
Siriraj Hospital
🇹🇭Bangkok, Thailand
Buddhachinaraj Phitsanulok Hospital
🇹🇭Phitsanulok, Thailand
Songklanagarind Hospital
🇹🇭Songkhla, Thailand
Royal Papworth Hospital NHS Foundation Trust
🇬🇧Cambridge, United Kingdom
Altnagelvin Area Hospital (WHSCT)
🇬🇧Londonderry, United Kingdom
Freeman Hospital
🇬🇧Newcastle, United Kingdom
North Tyneside General Hospital, Northumbria Healthcare
🇬🇧North Shields, United Kingdom
Southern Health & Social Care Trust
🇬🇧Portadown, United Kingdom
Northern General Hospital
🇬🇧Sheffield, United Kingdom
Lister Hospital East and North Hertfordshire NHS Trust
🇬🇧Stevenage, United Kingdom