Differential Expression Of IL6 And TNF Alpha In Symptomatic Pulpitis A Comparative Study In Diabetic And Non Diabetic Individuals
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- to evaluate levels of IL6 and TNF Alpha in type 2 diabetic and non diabetic pulpal blood.
研究概览
简要总结
This observational study aimed to compare the expression levels of pro-inflammatory cytokines Interleukin 6 and Tumor Necrosis Factor-alpha in patients with symptomatic pulpitis, focusing on differences between diabetic and nondiabetic individuals. A total of 70 patients will be enrolled and categorized based on their diabetic status. Pulpal samples were collected during routine endodontic access procedures, and cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA). The study sought to assess the influence of systemic diabetic status on local pulpal inflammation. These findings highlight the potential impact of systemic metabolic conditions like diabetes on the progression and severity of pulpal disease. The study emphasizes the importance of considering systemic health in the diagnosis and management of endodontic infections
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Medical Condition with Nondiabetic and type 2 Diabetic patients 2)Patients diagnosed with symptomatic pulpitis 3)Positive response to cold test 4)Teeth with adequate pulpal blood volume for biomarker analysis.
- •Willingness to Participate.
排除标准
- •Systemic Conditions Affecting Study Outcomes such as hyperparathyroidism, hyperthyroidism, hepatic or chronic renal disease.
- •Immunocompromised conditions 3)Pregnancy 4)Medication Use That Could Influence Inflammation levels 5)Negative response to cold test.
结局指标
主要结局
to evaluate levels of IL6 and TNF Alpha in type 2 diabetic and non diabetic pulpal blood.
时间窗: 8 Weeks
次要结局
未报告次要终点
研究者
Kanukurthi Meghana
MNR Dental college and Hospital