COMPARING INFLAMMATORY BIOMARKERS USING TWO MODES OF VENTILATION IN PATIENTS UNDERGOING LAPAROSCOPIC ABDOMINAL SURGERY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- 1. Plasma levels of biomarkers (IL6, IL8, TNF alpha, CRP, IL1, NLR, PLR) before induction and at 30 minutes post extubation in Post anesthesia care unit (PACU) in patients undergoing laparoscopic abdominal surgery. 2. Post operative atelectasis by modified lung ultrasound score (LUS) before induction and at 30 mins in Post anesthesia care unit (PACU) in patients undergoing laparoscopic abdominal surgery.
研究概览
简要总结
This study aims to fill this knowledge gap by comparing the levels of key inflammatory markers between patients ventilated with PCV-VG and those with VCV during elective laparoscopic abdominal surgeries. The findings may contribute to optimizing intraoperative ventilation strategies to enhance patient outcomes and minimize postoperative complications associated with atelectasis and inflammation.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18-65 years undergoing elective laparoscopic abdominal surgery under general anaesthesia requiring mechanical ventilation.
- •ASA Physical Status I-II.
排除标准
- •History of chronic lung or heart disease.
- •History of obstructive sleep apnea (OSA).
- •History of thoracic surgery or trauma.
- •BMI over 30kg/m2.
结局指标
主要结局
1. Plasma levels of biomarkers (IL6, IL8, TNF alpha, CRP, IL1, NLR, PLR) before induction and at 30 minutes post extubation in Post anesthesia care unit (PACU) in patients undergoing laparoscopic abdominal surgery. 2. Post operative atelectasis by modified lung ultrasound score (LUS) before induction and at 30 mins in Post anesthesia care unit (PACU) in patients undergoing laparoscopic abdominal surgery.
时间窗: Prior to induction and at 30 mins post extubation in post anaesthesia care unit
次要结局
- Post operative atelectasis by modified lung ultrasound score (LUS) before induction and at 30 mins in Post anesthesia care unit (PACU) in patients undergoing laparoscopic abdominal surgery.(Prior to induction and at 30 mins post extubation in post anaesthesia care unit)
研究者
Abhishek Sharma
Vardhman Mahavir medical college and Safdarjung hospital