18-Fluorothymidine positron emission tomography (18-FLT PET/CT) to assess tumour proliferation during radical radiotherapy

Not Applicable

Completed

• Conditions: Topic: National Cancer Research Network; Subtopic: Head and Neck Cancer, Lung Cancer; Disease: non small cell lung cancer; Cancer; Lung cancer

• Registration Number: ISRCTN97398362
• Lead Sponsor: Guy's and St. Thomas' NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-07-27
• Last Update Posted: 9 October 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. About to undergo radical radiotherapy for one of the following:
1.1. Non-small cell lung cancer with staging between I - III and either the primary tumour or an involved lymph node being greater than 3 cm in maximum dimension
1.2. Squamous cell carcinoma of the head and neck region with staging between II - IVA and either the primary tumour or an involved lymph node being greater than 3 cm in maximum dimension
2. Over 18 years of age, either sex
3. Able to understand consent form
4. Fit for extra incovenience of longer stays in hospital on days of scans
5. Receiving chemotherapy concurrently with radiotherapy

Exclusion Criteria

1. Patient unfit to attend extra scanning visits
2. Tumour criteria not met
3. Clotting disorder for head and neck group
4. Severe claustrophobia or inability to tolerate PET/CT
5. Unable to provide written consent
6. Pregnant or breastfeeding women
7. Subjects taking nucleoside analog medications such as those used as antiretroviral agents

Study & Design

• Study Type: Interventional
• Study Design: Not specified