Effect of Non Surgical Treatment of Periodontitis on Diabetes Control

Not Applicable

Completed

• Conditions: Periodontitis; Diabetes

• Registration Number: NCT02745015
• Lead Sponsor: Yaounde Central Hospital

Brief Summary

The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients. Patients with type two diabetes mellitus patients and confirmed chronic periodontitis will be selected and randomly assign to two groups. The treatment group will receive immediate full-mouth scaling and root planing whereas the control group will be scheduled to receive periodontal treatment at the following 3-month visit. Plaque index, bleeding index, probing pocket depth, recessions and cervical attachment loss will be recorded at baseline, at six weeks and at three months. Glycated haemoglobin (HbA1c) and C-reactive protein (CRP) will be analysed at baseline and three months following enrolment.

Detailed Description

The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients. Patients with type two diabetes mellitus patients and confirmed chronic periodontitis will be selected and randomly assign to two groups. The treatment group will receive immediate full-mouth scaling and root planing whereas the control group will be scheduled to receive periodontal treatment at the following 3-month visit. Plaque index, bleeding index, probing pocket depth, recessions and cervical attachment loss will be recorded at baseline, at six weeks and at three months. Glycated haemoglobin (HbA1c) and C-reactive protein (CRP) will be analysed at baseline and three months following enrolment.

Study Timeline

• Study Start: 2014-12
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Study First Submitted: 2016-04-16
• Study First Submitted QC: 2016-04-16
• Study First Posted: 2016-04-20
• Status Verified: 2016-07
• Last Update Submitted: 2016-07-17
• Last Update Posted: 2016-07-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Type 2 diabetes for at least one year
• periodontitis
• HbA1c > 7%

Exclusion Criteria

• Periodontal treatment in the last 6 months
• antibiotics in the last 3 months
• tobacco smoking
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Metabolic	3 months	Change in HbA1c

Secondary Outcome Measures

Name	Time	Method
Inflammation	3 months	change in CRP level between baseline and 3-month post intervention
Periodontal 1	3 months	Change in plaque index between baseline and 3-month post intervention
Periodontal 2	3 months	Change in bleeding index between baseline and 3-month post intervention
Periodontal 3	3 months	Change in pocket depth between baseline and 3-month post intervention

Trial Locations

Locations (1)

National Obesity Centre; 🇨🇲 Yaounde, Cameroon