Platelet responsiveness to Aspirin as measured using Light Transmission Aggregometry (LTA) and Thromboelastography with platelet mapping (TEG-PM) in children after Heart Surgery.

Children's Health Queensland Hospital and Health Service0 个研究点目标入组 132 人开始时间: 2023年11月23日最近更新: 2023年12月4日

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•Age 0-18 years of age
•Family/carer/patient able to provide informed consent.
•Children who require aspirin thromboprophylaxis after cardiac surgery such as;
•Systemic to pulmonary artery shunts
•Cavo-pulmonary shunt
•Fontan procedure
•Right ventricle to pulmonary artery conduit implantation
•Repairs involving large intra-cardiac baffles
•Valve repairs
•Any other patient receiving thromboprophylaxis with aspirin who does not meet the exclusion criteria

•Patients with documented allergic reaction to aspirin
•Patients in whom aspirin is contra-indicated due to past adverse reactions such as Reye’s syndrome or renal dysfunction
•Patients on long-term anticoagulation with other drugs in addition to aspirin e.g. warfarin, clopidogrel or other antiplatelet medications.
•Relative contraindication: Patients who had GI bleeds associated with aspirin in the past should be assessed carefully, but not excluded immediately, given that aspirin can cause gastritis in any patient if they are fasted, have a concurrent illness etc

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