NCT01820429已完成不适用
Residual Platelet Activity Despite Aspirin Utilization in Patients With Non ST Elevation Acute Coronary Syndromes: Comparison Between the Acute and Chronic Phases
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Compare platelet aggregation between the first 48 hours and 3 months after discharge.
研究概览
简要总结
The purpose of this study is to compare the response to aspirin in the acute phase with the late phase of an acute coronary syndrome.
详细描述
The purpose of this study is to compare, in the same population, the response to aspirin in the initial phase (first 48 hours) with the late phase (after 3 months of discharge)of a non ST elevation acute coronary syndrome (angina or acute myocardial infarction).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Confirmed diagnosis of acute coronary syndrome without ST segment elevation, in the first 48 hours after the onset of the clinical symptoms
- •Regular use of aspirin for at least seven days.
排除标准
- •Previous use, in the last 7 days, of another antiplatelet agent than aspirin
- •Use of antivitamin K in the last 3 weeks
- •Hemoglobin < 10g/dL and / or hematocrit < 30% or > 50%, platelets count < 100.000/mm3 or > 500.000/mm3, creatinine clearance < 30 mL / minute
- •Killip class III or IV
- •Need for vasopressor or inotropic parenteral medication at inclusion in the study
- •Percutaneous coronary intervention within 30 days or CABG in the last 90 days prior to study entry
- •Current malignancy
- •Hematologic diseases
- •Refusal to sign the inform consent form
- •Unable to attend the second visit (follow-up) for any reason except for death
结局指标
主要结局
Compare platelet aggregation between the first 48 hours and 3 months after discharge.
时间窗: 3 months
次要结局
- Relation between the atherosclerotic burden by coronary angiography with the platelet aggregation in the first 48 hours.(48 hours)
- Relation between C reactive protein and interleukin -6 with levels of platelet aggregation.(first 48 hours and 3 months)
- Relation between platelet aggregation and the presence or absence of selected polymorphisms.(first 48 hours and 3 months)
- Relation between platelet aggregability and the composite endpoint of death, myocardial infarction, unstable angina and need for revascularization or hospitalization at 3 months after discharge.(3 months)
- Platelet aggregation in respect to age, gender, glucose at hospital arrival, glycated hemoglobin, statin, PPI, current smokers, ACE inhibitors, type of ACS presentation.(first 48 hours and 3 months)
研究者
研究点 (1)
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