Platelet Reactivity and MES During CEA

• Conditions: Carotid Artery Stenosis; Ischemic Stroke; Myocardial Infarction; Aspirin Resistance

• Registration Number: NCT01547039
• Lead Sponsor: UMC Utrecht

Brief Summary

The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-03
• Study First Submitted: 2012-03-02
• Study First Submitted QC: 2012-03-02
• Study First Posted: 2012-03-07
• Last Update Submitted: 2012-03-08
• Last Update Posted: 2012-03-12
• Study Start: 2012-06
• Primary Completion: 2014-06
• Study Completion: 2014-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Al patients undergoing elective carotid endarterectomy

Exclusion Criteria

• Patients requiring a blood transfusion prior to surgery
• Patients with an inappropriate temporal bone window for transcranial Doppler (TCD)
• Patients on vitamin K antagonists or antiplatelet treatment other then aspirin
• Patients with an artificial cardiac valve

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microembolic signals (MES)	During and 1 hour following carotid endarterectomy (CEA)	Microembolic signals detected by transcranial duplex (TCD)

Secondary Outcome Measures

Name	Time	Method
Ischemic stroke	within 30 days postoperative
Asymptomatic perioperative myocardial injury	3 days postoperative	Troponin elevation \> 0.1 ng/ml
Myocardial infarction	Within 30 days postoperative

Trial Locations

Locations (1)

UMC Utrecht; 🇳🇱 Utrecht, Netherlands