Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient

• Conditions: End Stage Renal Disease

• Registration Number: NCT01045785
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The purpose of this study is to determine whether aspirin resistance has impact on cardiovascular event in dialysis patient.

Detailed Description

Dialysis patient inevitably suffered from uremic bleeding although improvement of dialysis care in the past decades. Physicians used to check bleeding time as a surrogate marker for uremic bleeding. However, bleeding time isn't accurate and as well known, is poorly correlated with clinical bleeding such as surgical bleeding. Platelet function assay (PFA) is a newly developed method to measure platelet aggregation in vitro and is validated in many sorts of platelet disorders. Recently, PFA was also used to evaluate aspirin responsiveness in patients who had taken aspirin. Our study is aim to investigate uremic thrombocytopathy via PFA of dialysis patient in Taiwan. Furthermore, we will study aspirin resistance in dialysis patient.

Study Timeline

• Status Verified: 2009-12
• Study Start: 2009-12
• Study First Submitted: 2010-01-08
• Study First Submitted QC: 2010-01-08
• Last Update Submitted: 2010-01-08
• Study First Posted: 2010-01-11
• Last Update Posted: 2010-01-11
• Primary Completion: 2010-06
• Study Completion: 2010-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• dialysis >3 months
• Hb>10 g/dl & Plt > 10000

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Exclusion Criteria

• using medication which interfere PFA except aspirin
• terminal disease such as malignancy
• active vasculitis

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cardiovascular event, bleeding event,and thrombosis	1 year

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan