NCT00262275已完成不适用
Optimum Platelet Inhibition After Coronary Artery Bypass Surgery: A Randomised Trial Comparing Platelet Aggregation Using Low, Medium Dose Aspirin and Clopidogrel
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 2
研究概览
简要总结
To investigate the effect of different dosages of aspirin on platelet aggregation and to determine the possible mechanisms of aspirin resistance, we intend to compare the effects of low, medium dose aspirin with clopidogrel (an alternative antiplatelet agent) in patients after coronary artery bypass surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •We intend to invite patients aged 18 to 80 proceeding to primary elective coronary artery bypass surgery, able to give informed consent.
排除标准
- •Preoperative exclusion criteria:
- •patients who are have not stopped aspirin 7 days prior to surgery
- •patients on concomitant NSAIDS
- •patients with a previous history platelet disorders, splenectomy or haematological disorders
- •patients with aspirin induced asthma
- •patients with any contraindications to aspirin (GI bleed)
- •patients who are on any medication that may result in a serious drug interaction with aspirin (warfarin)
- •Women of childbearing potential
- •Patients of less than 18 years
- •If informed consent cannot be obtained
- •If for any reason the consultant surgeon or anaesthetist deems it to be appropriate
- •Operative exclusion criteria:
- •Concomitant procedures
- •Postoperative exclusion criteria:
- •patients who receive platelet transfusion
- •patients who receive NSAIDS
- •requirement for intra aortic balloon pump support
- •failure of extubation within 24 hours
研究者
研究点 (2)
Loading locations...
相似试验
Unknown
不适用
Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis PatientEnd Stage Renal DiseaseNCT01045785National Taiwan University Hospital300
招募中
4 期
Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent ImplantationAntiplatelet AgentsPerioperative CareNCT06723145Kyoto University1,200
已完成
3 期
Platelet Drug Trial in Coronary Disease ProgressionCardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial IschemiaNCT00000496National Heart, Lung, and Blood Institute (NHLBI)
已完成
3 期
Antiplatelet Strategy for Peripheral Arterial Interventions for Revascularization of Lower ExtremitiesPeripheral Arterial DiseaseNCT02217501University of Texas Southwestern Medical Center159
已完成
3 期
Platelet-Inhibitor Drug Trial in Coronary AngioplastyCardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial IschemiaAngina PectorisNCT00000510National Heart, Lung, and Blood Institute (NHLBI)