Dose-related Effect of Aspirin on Laboratory-defined Acetylsalicylic Acid Resistance and Clinical Outcome After Coronary Stenting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- laboratory ASA resistance
研究概览
简要总结
The investigators prospectively studied the effect of aspirin on platelet function in 106 stable outpatients 6 months after successful percutaneous coronary angioplasty. Participants were randomized in a double-blind, double-crossover study (80 or 500 mg per day for 6 months).T
详细描述
Background:
Acetylsalicylic acid (aspirin) is widely used in the secondary prevention of coronary artery disease. There is controversy regarding the prevalence of aspirin resistance in patients with coronary artery disease and the effect of dose on resistance. Our primary aims were to determine the degree of platelet responsiveness to aspirin, and to study the influence of dose on platelet inhibition and clinical outcomes after coronary stenting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 67 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •6 months post stent without complication
排除标准
- •subacute stent thrombosis
- •unable to discontinue plavix
- •dont accept to participate
- •contraindication for ASA use
研究组 & 干预措施
80 mg ASA dose
6 months post stent on 80 mg ASA
干预措施: 80 mg ASA dosing (Drug)
500 mg ASA dose
6 months posr stent on ASA alone
干预措施: 500 mg ASA dosing (Drug)
结局指标
主要结局
laboratory ASA resistance
时间窗: 6 months
次要结局
- major adverse cardiac events and positive cardiac scan for ischemia(6 months)