Platelet Function in Patients With an Acute Coronary Syndrome

• Conditions: Acute Coronary Syndrome (ACS)

• Registration Number: NCT01992484
• Lead Sponsor: Medical University of Vienna

Brief Summary

The aims of the study are to:

* explore whether platelet reactivity in patients treated wih novel platelet inhibitors is associated with clinical outcome

* investigate whether a therapeutic window exist for novel platelet inhibitors

* investigate the incidence of adverse events under treatment with novel platelet inhibitors in the real life clinical scenario

* investigate the association between genetic polymorphisms, inflammation, platelet reactivity and clinical outcome

* investigate synergistic effects between aspirin and novel platelet inhibitors

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08
• Status Verified: 2013-11
• Study First Submitted: 2013-11-19
• Study First Submitted QC: 2013-11-19
• Last Update Submitted: 2013-11-19
• Study First Posted: 2013-11-25
• Last Update Posted: 2013-11-25
• Primary Completion: 2015-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Signed informed consent
• Acute coronary syndrome at admission
• Planned treatment with novel platelet inhibitors
• Age >18

Exclusion Criteria

* Participation in interventional trials

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Net clinical benefit.	1 year	A composite of MACE and BARC=\>2 bleedings.

Secondary Outcome Measures

Name	Time	Method
MACE and Major bleeding	1 year	MACE: the composite of stent thrombosis, cardiac death and myocardial infarction.; Major Bleeding: BARC =\>2, TIMI major, GUSTO moderate-severe-life threatening.

Trial Locations

Locations (1)

Medical Univerity of Vienna, Department of Cardiology; 🇦🇹 Vienna, Austria