Ovarian Tissue Cryopreservation As A Means Of Preserving Ovarian Function in Females Undergoing Therapeutic Procedures That Will Potentially Lead To The Irreversible Loss of Ovarian Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 4
- 主要终点
- Return of hormones produced by the ovarian tissue
研究概览
简要总结
The purpose of this study is to retrieve and cryopreserve ovarian tissue from females undergoing a treatment that may lead to irreversible loss of ovarian function.
详细描述
The aim of this preliminary study is to retrieve and properly cryopreserve ovarian tissue for autotransplantation in any premenopausal female whose ovarian function is threatened in a physiological, pathological or iatrogenic manner in an effort to observe the return of ovarian endocrine function and development of egg(s) appropriate for use in in vitro fertilization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patient must be female.
- •Patient must have a disease process where the disease or its treatment adversely affects ovarian function.
- •Patient must be recommended for this study by their oncologist or specialist.
- •Patient (or legally authorized representative) must sign an informed consent.
排除标准
- •Patients cannot be male.
- •Patients must not be HIV positive.
- •Patient cannot have a poor diagnosis such that she is not expected to survive to adulthood.
- •Patient cannot have any medical condition that would contraindicate surgery.
- •Patient cannot have any medical condition that would contraindicate general anesthesia.
- •Patient cannot have any medical condition that would contraindicate pregnancy.
研究组 & 干预措施
Retrieval and Cryopreservation
Females undergoing therapeutic procedures that will potentially lead to the irreversible loss of ovarian function will have their ovarian tissue retrieved and cryopreserved. Ideally, after treatment, the cryopreserved ovarian tissue can be thawed and auto-transplanted and ovarian function resumed.
干预措施: Retrieval and Cryopreservation (Procedure)
结局指标
主要结局
Return of hormones produced by the ovarian tissue
时间窗: 3 months after re-implantation
次要结局
- Development of egg(s) appropriate for use in in vitro fertilization(Participants will be followed through their reproductive years (until the patient reaches 45 years of age))
研究者
Estil Strawn
Professor, Director of Division of Reproductive Endocrinology and Infertility
Medical College of Wisconsin