Stepwise assessment of the relation between glycocalyx dimensions, oxidative stress and level of glycaemia
- Conditions
- Diabetes mellitushyperglycaemia10012653
- Registration Number
- NL-OMON32609
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Male
Caucasian race
Age 18-30 years
Exclusion Criteria
Diabetes mellitus or fasting glucose >5.5 mmol/l
Smoking
BMI > 25 kg/m2
Blood pressure >= 130 mmHg systolic; >= 90 mmHg diastolic
Total cholesterol >= 5 mmol/l, LDL-cholesterol >= 3 mmol/l or triglycerides >= 1.7 mmol/l
Use of lipid lowering or antihypertensive drugs
Use of antioxidants in the two weeks before the hyperglycemic clamp
Acute illness within 3 months before the study
Any other illness that inhibits participation in the study according to the study physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Relation between level of glycemia and glycocalyx thickness, relation between<br /><br>level of glycemia and ROS formation. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Relation between glycocalyx thickness and ROS formation, relation between level<br /><br>of glycemia and activation of coagulation parameters.</p><br>