The effects of repetitive tDCS on relapse in cocaine addiction: An ecological momentary assessment (EMA) study

Conditions: Verslaving
Drug dependence
Substance abuse

Registration Number: NL-OMON43214

Lead Sponsor: Erasmus Universiteit Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

Aged between 18 and 65 years
Meeting the DSM-V criteria for cocaine dependence
The ability to speak, read, and write in Dutch at an eight-grade literacy level
No severe withdrawal signs or symptoms at baseline

Exclusion Criteria

- Indications of severe psychopathology (psychosis, severe mood disorder) as assessed by a physician;
- A diagnosis of epilepsy, convulsions or delirium tremens during abstinence of cocaine;
- The intake of medications for psychiatric conditions;
- Any contraindication for electrical brain stimulation procedures such as electronic implants or metal implants;
- Pregnancy or breast-feeding.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Relapse probability in cocaine addicted patients as measured by means of EMA<br /><br>after twice daily sessions of bilateral tDCS (left cathodal/right anodal) over<br /><br>the DLPFC for five consecutive days. The primary study outcome is number of<br /><br>relapse days at three months follow-up.<br /><br>In addition, number of relapse days after one week, craving, temptations and<br /><br>cognitive control will be assessed as possible predictors of relapse days at 3<br /><br>months follow-up. Craving will be measured at the same moments in time as<br /><br>relapse, by means of five single EMA items. Cognitive control will be<br /><br>determined by inhibitory control and risky decision making. Inhibitory control<br /><br>will be measured by performance on NoGo trials in the Go/NoGo task. Mean number<br /><br>of pumps on the BART task will represent risk-taking. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The following control variables will be assessed: positive- and negative<br /><br>affect, alcohol/ drug use, life satisfaction, amount of drug use in the past<br /><br>month, starting age of using drugs and current age.</p><br>