Investigating the neural correlates of repeated tDCS in MCI and healthy ageing with fMRI

Completed

• Conditions: Alzheimer's disease; dementia; 10012272

• Registration Number: NL-OMON43086
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Patients
- Diagnosis of MCI based on the latest research criteria (clinical assessment at the memory clinic (prof. Frans RJ Verhey): presence of at least a memory impairment, memory complaints expressed by the patient or informant, no problems in daily life functioning, no dementia and presence of biomarkers (Albert et al., 2011)
- Clinical Dementia Rating score of 0.5 (CDR distinguishes a stage of questionable dementia (CDR 0.5) from people termed healthy (CDR 0) and those with mild dementia (CDR 1)
- Mini-Mental State Examination (MMSE) 23 and being mentally competent (in general, individuals with a MMSE 18 are considered mentally competent)
- Age: between 60 and 85 years old
- 50% female
- Right-handedness
- Average level of education (CBS level 3-4-5-6);Healthy controls
- Average neuropsychological test results, in accordance with normative data, corrected for age, education and gender
- No substantial memory complaints (according to the participant)
- Age: between 60 and 85 years old
- 50% female
- Right-handedness
- Average level of education (CBS level 3-4-5-6)
- Normal or corrected to normal vision

Exclusion Criteria

- Psychoactive medication use
- Abuse of alcohol and drugs
- Cognitive impairment due to alcohol/drug abuse or abuse of other substances
- Past or present psychiatric or neurological disorders (major depression, schizophrenia, bipolar disorder, psychotic disorder (or treatment for it), epilepsy, stroke, Parkinson*s disease, multiple sclerosis, brain surgery, brain trauma, electroshock therapy, kidney dialysis, Menière*s disease, brain infections)
- Major vascular disorders (e.g. stroke)
- Heart diseases or pacemakers
- Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, body tattoos)
- Large scars or fresh wounds on the scalp

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome measures are the Blood Oxygenation Level Dependent (BOLD)<br /><br>reflecting brain activity during the functional task and functional<br /><br>connectivity changes reflecting network integrity. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are performance on a pattern separation episodic<br /><br>memory task (accuracy and reaction times). Performance on the task will be<br /><br>correlated with BOLD-signal per session.</p><br>