A clinical trial to study the effect of brain stimulation by surface magnetic coil in patients with levodopa induced abnormal movements in parkinsons disease and abnormal movements in huntingtons chorea
Phase 1
- Conditions
- Health Condition 1: null- In patient who are ambulatory and having Parkinsons disease or Huntingtons diseaseHealth Condition 2: G20- Parkinsons disease
- Registration Number
- CTRI/2018/01/011359
- Lead Sponsor
- Vinay Goyal
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a) PD patients diagnosed with UKPD Brain bank criteria between age group of 45-75 years with levodopa induced dyskinesia
b) PD patients with stable medication for at least 30 days
c) PD patients of both sexes with modified Hoen and Yahr stage-2.5-4
d) HD patients with disabling chorea (Fahn and shoulson stage 2 to 4) and non-responsive to neuroleptics
Exclusion Criteria
a) Features of Atypical Parkinsonism
b) History of neurosurgery on brain
c) Family (1st degree relatives) history of epilepsy
d)History of psychiatric disorders (schizophrenia, schizoaffective disorder, other psychosis, claustrophobia; rapid-cycling bipolar illness, alcohol/drug abuse) within the past year
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In case of parkinsonsâ??s disease, the outcome measures studied are the change in UDysR(Unified dyskinesia rating) score pre(1st day) and post rTMS(5th day). <br/ ><br>In case of Huntingtonâ??s disease, the outcome measures studied are the changes in the UHDRS(Unified huntingtons disease rating) and AIMS(Abnormal involuntary movement score) scores pre rTMS(1st day) and post rTMS(5th day) <br/ ><br>Timepoint: 1st and 5th day
- Secondary Outcome Measures
Name Time Method The percentage of levodopa induced dyskinesias(LIDs) monitored with hausers motor diary over next 4 weeksTimepoint: At the end of 4 weeks