Clinical effectiveness of repetitve transcranial magnetic stimulation (rTMS) as an adjunctive therapy in depression - a catchment area-based randomised controlled trial

Completed

• Conditions: Major depressive disorder; Mental and Behavioural Disorders; Depression

• Registration Number: ISRCTN70121208
• Lead Sponsor: South London and Maudsley NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03-05
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 54

Inclusion Criteria

Over 18 years old, right-handed and have a diagnosis of major depressive disorder (DSM-IV)

Exclusion Criteria

1. History of seizures
2. Head injury with loss of consciousness
3. Brain surgery
4. Presence of metallic implants
5. Evidence of dementia or other Axis 1 diagnosis
6. Substance misuse within the previous six months
7. Previous treatment with rTMS
8. Inability to provide informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hamilton Rating Scale for Depression (HDRS)

Secondary Outcome Measures

Name	Time	Method
Clinical: <br>1. Beck Depression Inventory-II (BDI-II)<br>2. Visual Analogue Mood Scales (VAMS)<br>3. Brief Psychiatric Rating Scale (BPRS) <br><br>Subjective side-effects: <br>1. Modified Columbia ECT Subjective Side Effects Schedule (CSSES) <br><br>Cognition: <br>1. CAMCOG, digit-span test<br>2. Digit symbols modalities test<br>3. Grooved pegboard test <br><br>Quality of life: <br>SF-36 questionnaire<br><br>Economic: <br>Client Service Receipt Inventory (CSRI)