Evaluation of effects of transcranial magnetic stimulation in Parkinsons disease patients with freezing of gait
Not Applicable
- Conditions
- Health Condition 1: G20- Parkinsons disease
- Registration Number
- CTRI/2020/06/025515
- Lead Sponsor
- ICMR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Idiopathic PD patients aged 50-80years of age presenting with FOG
2. Modified Hoehn & Yahr scale 1.5-3
3. On Stable dopaminergic medicine for past 3 months
4. The mini-mental state examination (MMSE) questionnaire score > 24 points
5. Informed written consent
Exclusion Criteria
1. History of brain tumour, stroke, traumatic brain injury, epilepsy or seizure in lifetime
2. History of major depression, psychosis, dementia (MMSE�24)
3. Implanted pacemaker, intra-cardiac lines, pumps or stimulators, or metallic foreign bodies inside the eye or skull (Dental fillings and braces are allowed)
4. Pregnancy (negative UPT in 2 weeks)
5. History of exposure to rTMS in the past
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in the FOG Q score pre treatment (T0) & post treatment between two groups (T1, T2 & T3)Timepoint: T0 baseline <br/ ><br>T1after 5th session of sham rTMS <br/ ><br>T2 after 5th session of real rTMS <br/ ><br>T3 after 4 weeks
- Secondary Outcome Measures
Name Time Method Change in UPDRS motor score, LED &PDQ 39 pretreatment (T0) & post treatment between two groups (T1, T2 & T3)Timepoint: T0 baseline <br/ ><br>T1after 5th session of sham rTMS <br/ ><br>T2 after 5th session of real rTMS <br/ ><br>T3 after 4 weeks