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Clinical Trials/NCT04401397
NCT04401397
Completed
Not Applicable

The Effect of Inpatient Intensive Early Mobilisation Intervention on Length of Hospital Stay, Medical and Functional Recovery and Readmission Rate of Patients After CABG or AVR/MVR: A Randomized Single Blind Controlled Clinical Trial.

Dimitris Chatzitheodorou1 site in 1 country40 target enrollmentJune 3, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Coronary Artery Disease
Sponsor
Dimitris Chatzitheodorou
Enrollment
40
Locations
1
Primary Endpoint
High cost medical procedures
Status
Completed
Last Updated
5 years ago

Overview

Brief Summary

The present study will investigate the volume and extent of the expected physiological effects of "early mobilization" on the prevention of the clinical illness' detrimental sequelae and on the functional recovery promotion of CABG, AVR and MVR patients. Consequently, it will investigate if the improved health outcomes may limit the number and intensity of complications and thus if it may speed up hospital discharge.

Detailed Description

Although the effects of "early mobilization" have been studied mainly in the intensive care unit setting, the findings could be applied to the surgical units' patients too, since they share common physiological and clinical characteristics. In the literature the effectiveness of "early mobilization" in the length of hospital stay and recovery of the patients operated for coronary artery bypass graft and heart valve replacement in the cardiac surgery setting, is unknown. The term "early mobilization" is not restricted to a time factor procedure but contains the provision of a customized dynamic set of physical therapy techniques which in studies are variably determined in terms of duration, intensity, frequency and content. The aim of the study is to determine the clinical effectiveness of the intensive early mobilization physical therapy intervention compared with standard care of physical therapy in the cardio-thoracic surgery clinic of Papageorgiou General Hospital of Thessaloniki. The present study will investigate the volume and extend of the expected physiological effects of "early mobilization" on the prevention of the clinical illness' detrimental sequelae and on the functional recovery promotion, hospital mortality and readmission rate of CABG, AVR and MVR patients. Consequently, it will investigate if the improved health outcomes may limit the number and intensity of complications and thus may speed up hospital discharge. In the first group of the experimental design, patients will be treated with an intensive early mobilization protocol and the patients of the second group will receive a standard care physical therapy treatment. Controlling for the detailed baseline characteristics that will be assessed during medical history at admission, potential bias will be limited from unmeasured confounders of the study.

Registry
clinicaltrials.gov
Start Date
June 3, 2020
End Date
December 23, 2020
Last Updated
5 years ago
Study Type
Interventional
Study Design
Factorial
Sex
All

Investigators

Sponsor
Dimitris Chatzitheodorou
Responsible Party
Sponsor Investigator
Principal Investigator

Dimitris Chatzitheodorou

Principal Investigator, Senior Physical Therapist

Papageorgiou General Hospital

Eligibility Criteria

Inclusion Criteria

  • Elective CABG or AVR or MVR surgery
  • No previous CABG or valve surgery
  • Isolated / multivessel CABG

Exclusion Criteria

  • Current neurological disorders
  • Previous cerebral vascular accident with residual neurological deficit significant enough to limit exercise
  • Significant limiting comorbidities that would prevent full participation

Outcomes

Primary Outcomes

High cost medical procedures

Time Frame: Up to 6 weeks

The number of high cost medical procedures the patients will undergo during their postoperative stay in the ward.

Severity of complications

Time Frame: Up to 6 weeks

Classification of the complications as "minor" or "major" according to the physicians' expert opinion based on published clinical standards.

Length of postoperative hospital stay

Time Frame: Up to 6 weeks

The number of postoperative days that the patients stay in the ward after their surgery procedure and ICU discharge.

Number of complications

Time Frame: Up to 6 weeks

The total number of medical events the patients will develop during their postoperative stay in the ward.

Readmission rate

Time Frame: Up to 6 weeks

The number of discharged patients that will be readmitted in the hospital for a condition of their underlying disease in a 30 days period after surgery.

Two-minute walk test

Time Frame: Up to 6 weeks

The distance in meters that a patient can walk under the specific test conditions, at the day of discharge.

Functional recovery

Time Frame: Up to 6 weeks

The time in days that is required for the patients to be autonomous in accessing and using the toilet in their ward.

Time to regain hemodynamic stability

Time Frame: Up to 6 weeks

The time in days that is required for the patients to be without inotrope or vasodilator drugs and remain normal and stable in arterial blood pressure, heart rate and blood gas rates.

Secondary Outcomes

  • Hospital mortality(Up to 6 weeks)

Study Sites (1)

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