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Impact of Early Mobilization on SAH Patients Physiological Parameters

Not yet recruiting
Conditions
Subarachnoid Hemorrhage
Interventions
Device: lung ultrasound
Device: Transcranial Doppler
Device: near-infrared spectroscopy (NIRS)
Device: clinical examination
Registration Number
NCT06286683
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Brief Summary

The aim of the study is to evaluate the physiological response to out-of-bed mobilization in patients admitted to the intensive care unit for subarachnoid hemorrhage. More specifically, the aim is to measure the impact on cerebral perfusion, lung aeration, cardiovascular and respiratory parameters.

Detailed Description

In patients with subarachnoid hemorrhage, the mobilization strategy has been little studied. Several studies have already evaluated the consequences of mobilization in bed. Because of the deleterious consequences of prolonged bed rest, and in line with recommendations, practices have evolved towards early out-of-bed mobilization, which has shown benefits. However, the physiological consequences of out-of-bed mobilization have not yet been assessed. The aim of this study is to measure the impact of early out-of-bed mobilization of patients admitted for SAH on neuro-cardio-pulmonary physiological parameters.

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
100
Inclusion Criteria

Age ≥ 18 years

  • Aneurysmal SAH
  • Severity score World Federation Neurological Surgeons I to IV
  • Secured aneurysm
  • Eligible for their first early mobilization
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Exclusion Criteria
  • Sedated patient
  • Disturbed alertness, coma
  • Unsecured aneurysm
  • Patients under legal protection (guardianship, curatorship, safeguard of justice)
Read More

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Patients admitted to intensive carenear-infrared spectroscopy (NIRS)Patients admitted to intensive care for aneurysmal subarachnoid hemorrhage (SAH) and eligible for their first out-of-bed mobilization
Patients admitted to intensive carelung ultrasoundPatients admitted to intensive care for aneurysmal subarachnoid hemorrhage (SAH) and eligible for their first out-of-bed mobilization
Patients admitted to intensive careclinical examinationPatients admitted to intensive care for aneurysmal subarachnoid hemorrhage (SAH) and eligible for their first out-of-bed mobilization
Patients admitted to intensive careTranscranial DopplerPatients admitted to intensive care for aneurysmal subarachnoid hemorrhage (SAH) and eligible for their first out-of-bed mobilization
Primary Outcome Measures
NameTimeMethod
Impact on lung aerationat T0 before initiation of out-of-bed mobilization, and 15 minutes after moving to the chair.

Lung Ultrasound Score by lung ultrasound, Ranging from 0 (normal lungs) to 36 (worst case scenario).

Secondary Outcome Measures
NameTimeMethod
Impact on neurological examinationAt T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.

Glasgow Coma Scale score (scored between 3 and 15, 3 being the worst and 15 the best)

Impact on patient comfortAt T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.

Numerical Pain Rating Scale (scored between 0 and 10, 0 being "no pain",10 "the worst pain imaginable")

Impact on heart rateAt T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.

Heart rate

Impact on arterial pressureAt T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.

Arterial pressure

Impact on SaturationAt T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.

Saturation

Impact on cerebral tissue oxygenationAt T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.

cerebral tissue oxygenation via NIRS

Impact on cerebral blood flowAt T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.

cerebral blood flow using average velocities on transcranial Doppler

Trial Locations

Locations (1)

Adéla FOUDHAÏLI

🇫🇷

Paris, France

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