Cerebral Dynamic Perfusion Study With Spectral CT in Patients Suspected of Stroke
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Cerebral Blood Volume (CBV)
Study Overview
Brief Summary
- Generate a dynamic mapping of the distribution of iodine within the cerebral parenchyma in the patient suspected of acute ischemic disorder with the CT spectral scanner.
- Correlate the anomalies of iodine mapping to the other parameters acquired during the classic dynamic infusion phase to define the ischemic area (MTT higher and rCBV normal) versus infarcted zone (MTT higher and rCBV decreased)
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to 95 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Clinical suspicion of hyperacute stroke (6 hours after onset of symptoms)
- •Age between 50 and 95 years
- •Weight: between 65 and 95 kg
Exclusion Criteria
- •Documented or suspected allergy to IV iodinated contrast media
- •Renal impairment with creatinine clearance <60 ml / min
- •Hemorrhagic lesions or vascular abnormalities demonstrated on CT before contrast injection
Arms & Interventions
Stroke
Clinical suspicion of hyperacute stroke (6 hours after onset of symptoms):Intervention 'spectral CT'
Intervention: spectral CT (Radiation)
Outcomes
Primary Outcomes
Cerebral Blood Volume (CBV)
Time Frame: from start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
CBV is measured in units of milliliters of blood per 100 g of brain and is defined as the volume of flowing blood for a given volume of brain.
Mean Transit Time (MTT)
Time Frame: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
MTT is measured in seconds and defined as the average amount of time it takes blood to transit through the given volume of brain.
Cerebral Blood Flow (CBF)
Time Frame: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)
CBF is measured in units of milliliters of blood per 100 g of brain tissue per minute and is defined as the volume of flowing blood moving through a given volume of brain in a specific amount of time.
Secondary Outcomes
No secondary outcomes reported