Effects of Stochastic Resonance Electrical Stimulation on Post Stroke Cortical Plasticity and Motor Function Recovery
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- EEG
研究概览
简要总结
This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.
详细描述
Stroke is one of the leading causes of motor disability. The main intervention strategy in stroke rehabilitation is to induce cortical plasticity for motor re-learning.
It has been demonstrated that electrical stimulation applied to the periphery can elicit abundant sensory afferent inputs to enhance excitability and activation area in the sensorimotor cortex. Recent evidence suggested that a new type of electrical stimulation pattern, stochastic resonance stimulation, is capable of efficiently enhancing the activation of peripheral and central nervous system. Therefore, the purpose of this study are to identify the effects of stochastic resonance electrical stimulation on neuromuscular control and proprioception, and to investigate the effectiveness of combining stochastic resonance electrical stimulation with rehabilitation program on post stroke motor function recovery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •In first stage
- •Inclusion Criteria:
- •healthy adults without history of neurological disorders or limitation in range of motion for thumb flexion
- •In the second stage
- •Inclusion Criteria:
- •first-ever cerebral cortical region involved chronic stroke, onset over a month
- •able to perform active grasp on the affected side with the scores of manual muscle test at least two points
- •at stable medical condition for intervention confirmed by a specialized physician.
排除标准
- •history of other neurological disorders
- •cognitive impairment (Mini-Mental State Examination score < 24, MMSE)29
- •unable to follow instructions
- •contraindications of ES
- •under 20 years old.
研究组 & 干预措施
stochastic resonance
stochastic resonance electrical stimulation is applied to the upper extremity during the subjects perform upper extremity motor function.
干预措施: stochastic resonance electrical stimulation (Other)
sham stimulation
sham electrical stimulation (same electrode location, but no electrical current is applied) is applied to the upper extremity during the subjects perform upper extremity motor function.
干预措施: stochastic resonance electrical stimulation (Other)
结局指标
主要结局
EEG
时间窗: baseline and one minute after stimulation
we will calculate power spectral and see whether change in the alpha, beta, theta band
Fugl-Meyer Assessment for Upper Extremity
时间窗: baseline and one minute after stimulation
changes in upper extremity function of the stroke subjects
次要结局
- muscle activation(baseline and one minute after stimulation)
- force deviation(baseline and one minute after stimulation)
- joint angle(baseline and one minute after stimulation)