Acute Effects From Prolonged Inactivity and Physical Activity Interventions on Cortical Blood Flow and Arterials Stiffness in School-aged Adolescents.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Changes in cerebral blood flow
研究概览
简要总结
The main aim for this study is to investigate to what extent physical activity of moderate or low intensity, relative to prolonged inactivity, may acutely alter neural activity-related prefrontal cortex oxygenated hemoglobin during a cognitive demanding task in 13- 15 year-old adolescents. The study is primarily focused on investigating these effects in ecologically valid conditions, i.e. activity patterns that closely resemble a typical day in school and using activity modes that are suitable in a school setting.
详细描述
The study will be a controlled crossover experimental trial with three conditions. Each participant will complete each of the three experimental conditions, separated by a washout period of minimum four days. Physical activity behaviours and sleep will be monitored the day/night before each test day. The first visit will be a familiarization session for the collection of demographic data, fitness testing, and acquaintance with experimental procedures. On the second, third, and fourth visits, participants will undergo three different standardized 80-minutes interventions in a randomized order. Before and immediately after the 80-minutes interventions, blood pressure, augmentation index, and cerebral hemodynamic response of the prefrontal cortex during standardized cognitive tasks (nback test) will be measured. Additionally, saliva samples will be collected the morning of the test day, and before and after the interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Exclusion Criteria:
- •Ongoing medication that can affect central circulation or brain circulation
- •Ongoing infection
- •Inability to apprehend information about the study or to perform the tests
排除标准
- •Ongoing medication that can affect central circulation or brain circulation
- •Ongoing infection
- •Inability to apprehend information about the study or to perform the tests
结局指标
主要结局
Changes in cerebral blood flow
时间窗: before to after 80 minutes intervention
Oxygenated and deoxygenated hemoglobin concentration changes measured with functional near-infrared spectroscopy
次要结局
- Cortisol(morning; before and after 80 minutes intervention)
- Mood(at the beginning of the day; before and after 80 minutes intervention)
- Cognitive performance(before and after 80 minutes intervention)
- Augmentation index(before and after 80 minutes intervention)
- Sleepiness(at the beginning of the day; before and after 80 minutes intervention)
- Alertness(at the beginning of the day; before and after 80 minutes intervention)