Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study

Completed

• Conditions: Respiratory Failure; Acute Lung Injury; Mechanical Ventilation
• Interventions: Other: For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube.

• Registration Number: NCT01628523
• Lead Sponsor: Washington University School of Medicine

Brief Summary

Despite its life-saving potential, the mechanical ventilator has great potential to do harm. Despite years of research, the mortality in acute lung injury (ALI) remains very high. Treatment options after ALI onset are very limited, therefore prevention may be the best option. Unfortunately, the emergency department has not been studied with respect to mechanical ventilation practices, and its contribution to ALI is unknown. The investigators hypothesize that mechanical ventilation is frequently used in the ED and for a variety of reasons, and that ED mechanical ventilation has an effect on long term outcomes.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2012-06-20
• Study First Submitted QC: 2012-06-25
• Study First Posted: 2012-06-26
• Study Start: 2012-07
• Primary Completion: 2013-08
• Study Completion: 2014-03
• Results First Submitted: 2015-03-02
• Status Verified: 2020-03
• Results First Submitted QC: 2020-03-09
• Last Update Submitted: 2020-03-09
• Results First Posted: 2020-03-23
• Last Update Posted: 2020-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 219

Inclusion Criteria

• Ventilation either via an endotracheal tube or tracheostomy

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Exclusion Criteria

• Non-invasive positive pressure ventilation;
• Death in the immediate post-intubation phase of care;
• Chronic ventilator-dependence, either at home or extended care facility.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
All ED patients requiring mechanical ventilation	For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube.	-

Primary Outcome Measures

Name	Time	Method
To Further Characterize ED Mechanical Ventilation	1 month	In a prospective cross-sectional study design, we will enroll all patients receiving mechanical ventilation in the ED over a one-month time frame.

Secondary Outcome Measures

Name	Time	Method
The Incidence of ARDS in Mechanically Ventilated Emergency Department Patients, and Risk Factors Associated With Progression to ARDS	1 month	Development of ARDS after admission to the hospital

Trial Locations

Locations (4)

University of Cincinnati College of Medicine; 🇺🇸 Cincinnati, Ohio, United States

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States

Christiana Care Health System; 🇺🇸 Newark, Delaware, United States

University of Iowa College of Medicine; 🇺🇸 Iowa City, Iowa, United States