Acute Effects of Cold Exposure on Cognitive Function and Underlying Mechanism
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cognitive Function
- Sponsor
- Fudan University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Results of Stroop Tests
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low-temperature exposure on cognitive function and the underlying mechanisms.
Detailed Description
The investigators will conduct a randomized controlled human exposure crossover study among about 40 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the low temperature (15℃) and once to the moderate temperature (22℃) in a chamber for about 2 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted immediately prior to exposure, during the period of exposure, and after exposure. Health examinations include cognitive function tests and magnetic resonance imaging. Investigators plan to collect blood and urine samples.
Investigators
Renjie Chen
Professor
Fudan University
Eligibility Criteria
Inclusion Criteria
- •Living in Shanghai during the study period;
- •Body mass index \> 18.5 and ≤ 28;
- •right-handed;
- •receiving or having received higher education;
- •with the ability to read and understand Chinese smoothly.
Exclusion Criteria
- •Smoking and alcohol abuse;
- •Current drug and dietary supplements intake;
- •Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy;
- •Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension;
- •Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
- •Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease;
- •Subjects who have a history of major surgery due to the cardiovascular, cerebrovascular, respiratory, or neurological diseases;
- •Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia;
- •Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65);
- •Subjects with color vision disabilities.
Outcomes
Primary Outcomes
Results of Stroop Tests
Time Frame: before exposure and immediately after the exposure session
Investigators plan to measure the changes of cognitive function using Stroop Test. The time taken to complete the test could reflect cognitive function, and a shorter time means better cognitive function.
Secondary Outcomes
- Results of simple reaction time(before exposure and immediately after the exposure session)
- Activated brain regions demonstrating neural activity related to the high temperature exposure(1 hour after exposure session)
- Activated brain regions demonstrating neural connectivity related to the high temperature exposure(1 hour after exposure session)
- Activated brain regions demonstrating neural synchronization related to the high temperature exposure(1 hour after exposure session)
- Changes of skin temperature(Skin temperature will be examined during the 2-hour exposure session (i.e., 1:00 P.M. to 3:00 P.M. on the day of the exposure session))