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Clinical Trials/NCT00772096
NCT00772096
Completed
Phase 4

Septic Encephalopathy and Late Cognitive Dysfunction in Patients With Sepsis - the Role of Inflammation

University Hospital, Basel, Switzerland1 site in 1 country50 target enrollmentOctober 2008
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ConditionsSepsisSevere Sepsis
Interventionsn-3 fatty acids
Drugsn-3 fatty acids

Overview

Phase
Phase 4
Intervention
n-3 fatty acids
Conditions
Sepsis
Sponsor
University Hospital, Basel, Switzerland
Enrollment
50
Locations
1
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaArms & InterventionsOutcomesSitesSimilar Trials

Overview

Brief Summary

Delirium and long-term cognitive dysfunction are important problems in intensive care patients. Patients with sepsis are at a high risk of developing delirium (septic encephalopathy), which may be an important risk factor for the development of long-term cognitive dysfunction.

Working hypotheses: 1. Septic encephalopathy and cognitive dysfunction are caused by an unspecific reaction of the brain to an intense inflammatory stimulus. 2. It is possible to therapeutically influence the inflammatory response and its effects on the brain.

Registry
clinicaltrials.gov
Start Date
October 2008
End Date
June 2011
Last Updated
11 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
University Hospital, Basel, Switzerland
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Admitted to an intensive care unit for treatment of sepsis, severe sepsis or septic shock
  • •Age 18 or older

Exclusion Criteria

  • •Primary infection of the CNS
  • •History of cerebrovascular disease
  • •History of any neoplasia involving the CNS
  • •History of long-term psychiatric medication
  • •History of allergy to fish- or egg-protein
  • •Severe coagulation abnormalities
  • •Clinical signs of altered coagulation, active bleeding
  • •Pregnancy

Arms & Interventions

Verum

Intervention: n-3 fatty acids

Outcomes

Primary Outcomes

Not specified

Study Sites (1)

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