Diastolic Function in Myotonic Dystrophy Type 1
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diastolic Dysfunction
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- mortality
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders. Mortality are mainly related to respiratory failure and sudden death. Patients with DM1 may suffer from obesity, arterial hypertension, diabetes mellitus and sleep apnea. These comorbidities are classically associated with left ventricular diastolic dysfunction (DD) .
The investigators aim to assess the prevalence of left ventricular diastolic dysfunction in patients with myotonic dystrophy type 1 , the distribution of DD grading as well as the long-term prognosis of DM1 patients with a left ventricular diastolic dysfunction.
Investigators
Abdallah FAYSSOIL
Associate Professor
Centre d'Investigation Clinique et Technologique 805
Eligibility Criteria
Inclusion Criteria
- •patients with genetic proven myotonic dystrophy type 1
- •who experienced a Doppler- Echocardiography including an assessment of the left ventricular diastolic function
Exclusion Criteria
- •wall motion basal abnormalities
- •significant valvular disease
Outcomes
Primary Outcomes
mortality
Time Frame: 7 years
Secondary Outcomes
- Incidence of arrhythmia(7 years)
- acute heart failure(7 years)