Diastolic Function in Myotonic Dystrophy Type 1
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- mortality
研究概览
简要总结
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders. Mortality are mainly related to respiratory failure and sudden death. Patients with DM1 may suffer from obesity, arterial hypertension, diabetes mellitus and sleep apnea. These comorbidities are classically associated with left ventricular diastolic dysfunction (DD) .
The investigators aim to assess the prevalence of left ventricular diastolic dysfunction in patients with myotonic dystrophy type 1 , the distribution of DD grading as well as the long-term prognosis of DM1 patients with a left ventricular diastolic dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with genetic proven myotonic dystrophy type 1
- •who experienced a Doppler- Echocardiography including an assessment of the left ventricular diastolic function
排除标准
- •wall motion basal abnormalities
- •significant valvular disease
结局指标
主要结局
mortality
时间窗: 7 years
次要结局
- Incidence of arrhythmia(7 years)
- acute heart failure(7 years)
研究者
Abdallah FAYSSOIL
Associate Professor
Centre d'Investigation Clinique et Technologique 805