Cardiac and Respiratory Prognostic Factors in Patients With Myotonic Dystrophy Type 1
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myotonic Dystrophy
- Sponsor
- Institut de Myologie, France
- Enrollment
- 914
- Locations
- 1
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
Myotonic dystrophy type 1 (DM1) is the most frequent neuromuscular disease in adults. DM1 patients have an impaired prognosis (mean age of death <60 years) due to cardiac and respiratory complications.
Our primary objective was to identify cardiac and respiratory prognostic factors in DM1.
Detailed Description
1. Patients with genetically proven DM1 who were admitted in Pitié Salpêtrière Hospital from 2000 and 2010 will be identified. These patients systematically underwent neurological, cardiac and respiratory investigations. 2. Baseline medical and genetic information will be entered in a dedicated database, including cardiac and respiratory investigations. 3. The occurence of severe cardiac and respiratory adverse events will also be collected. 4. Statistical analysis will be performed to look for correlations between baseline patient characteristics and cardiac or respiratory adverse events during follow up.
Investigators
Karim WAHBI
Karim WAHBI MD,PHD.
Institut de Myologie, France
Eligibility Criteria
Inclusion Criteria
- •DM1 mutation (\>50 CTG repeats)
- •Age \> 18 years
Exclusion Criteria
- •Patient refusal
Outcomes
Primary Outcomes
Not specified