Mechanisms of chronic pain and fatigue
- Conditions
- Specialty: Musculoskeletal disorders, Primary sub-specialty: Musculoskeletal Pain DisordersUKCRC code/ Disease: Musculoskeletal/ Other soft tissue disordersMusculoskeletal DiseasesMusculoskeletal Pain Disorders
- Registration Number
- ISRCTN78820481
- Lead Sponsor
- Brighton and Sussex University Hospitals NHS Trust
- Brief Summary
2020 Preprint results in https://www.medrxiv.org/content/10.1101/2020.02.21.20025072v1 non-peer-reviewed results in preprint 2021 Other publications in https://doi.org/10.7861/clinmed.2020-0743 Beyond bones: The relevance of variants of connective tissue (hypermobility) to fibromyalgia, ME/CFS and controversies surrounding diagnostic classification: an observational study (added 11/10/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 105
1. Participants must be capable of giving informed consent
2. All participants must be aged 18 or over
3. Healthy controls – free from major medical or psychiatric illness
4. Patients – meet diagnostic criteria for Fibromyalgia and/or ME/Chronic Fatigue Syndrome; they will then be stratified into the above groups
All participants:
1. Not able to give informed consent
2. Age under 18
3. Needle phobia
4. MRI incompatibility
5. Presence of metal work (e.g pacemaker) in body
7. Claustrophobia
8. Inability to lie still for one hour
9. Pregnancy
10. Previous adverse reaction to Typhoid Vaccination
Healthy controls:
Major medical or psychiatric illness
Patient participants:
Major neurological illness
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effects of a systemic inflammatory challenge (typhoid injection) on human brain microstructure is measured using quantitative magnetization transfer (qMT) imaging at visit two or visit three (randomized).
- Secondary Outcome Measures
Name Time Method