Rehydration Efficiency During Ad-libitum Fluid Intake
- Conditions
- Dehydration
- Interventions
- Other: Plain WaterOther: Liquid IV Sugar FreeOther: Liquid IV Hydration Multiplier
- Registration Number
- NCT06414291
- Lead Sponsor
- Arizona State University
- Brief Summary
It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.
The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Age 18-60 years
- Training at least 2 times per week
- stable weight for the last 2 months (fluctuation less than 5 pounds)
- Night shifting work
- Thyroid medication
- Bariatric surgery
- Cardiovascular disease
- Renal disease
- Hepatic disease
- Participating in another study at the same time
- Bodyweight over 110 pounds
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Water Plain Water Rehydration with low mineral content bottle water Low Sugar electrolyte solution Liquid IV Sugar Free 10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV Carbohydrate Electrolyte solution Liquid IV Hydration Multiplier Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV
- Primary Outcome Measures
Name Time Method Cumulative urine output during the first 4 hours of rehydration Total amount of urine output during rehydration
Total fluid intake 4 hours of rehydration Total amount of fluid ingested
Rate of absorption during the first 240 minutes of rehydration The rate of Deuterium appearance in the blood during 240 minutes of rehydration
Net fluid balance at 3 hours of the rehydration period amount of water retained during the rehydration period
- Secondary Outcome Measures
Name Time Method Plasma copeptin at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period Plasam Copeptin during rehydration
Stomach fullness at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period Stomach fullness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception
Free Osmotic Clearance at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period Free Osmotic clearance calculated based on plasma and urine osmolality
Thirst at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period Thirst estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception
Free water Clearance at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period Free water clearance calculated based on plasma and urine osmolality
Plasma volume at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period percent of plasma volume recovery during the rehydration
Taste Likeness at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period Taste Likeness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception
Trial Locations
- Locations (1)
Interdisciplinary Science and Technology Building 8
🇺🇸Phoenix, Arizona, United States